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Interplay between NS3 protease and human La protein regulates translation-replication switch of Hepatitis C virus
HCV NS3 protein plays a central role in viral polyprotein processing and RNA replication. We demonstrate that the NS3 protease (NS3(pro)) domain alone can specifically bind to HCV-IRES RNA, predominantly in the SLIV region. The cleavage activity of the NS3 protease domain is reduced upon HCV-RNA bin...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210691/ https://www.ncbi.nlm.nih.gov/pubmed/22355520 http://dx.doi.org/10.1038/srep00001 |