Next-Generation Sequencing of Apoptotic DNA Breakpoints Reveals Association with Actively Transcribed Genes and Gene Translocations

DNA fragmentation is a well-recognized hallmark of apoptosis. However, the precise DNA sequences cleaved during apoptosis triggered by distinct mechanisms remain unclear. We used next-generation sequencing of DNA fragments generated in Actinomycin D-treated human HL-60 leukemic cells to generate a h...

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Detalles Bibliográficos
Autores principales: Fullwood, Melissa J., Lee, Joanne, Lin, Lifang, Li, Guoliang, Huss, Mikael, Ng, Patrick, Sung, Wing-Kin, Shenolikar, Shirish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210745/
https://www.ncbi.nlm.nih.gov/pubmed/22087219
http://dx.doi.org/10.1371/journal.pone.0026054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210745/
https://www.ncbi.nlm.nih.gov/pubmed/22087219
http://dx.doi.org/10.1371/journal.pone.0026054

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