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Conformational Toggling of Yeast Iso-1-Cytochrome c in the Oxidized and Reduced States
To convert cyt c into a peroxidase-like metalloenzyme, the P71H mutant was designed to introduce a distal histidine. Unexpectedly, its peroxidase activity was found even lower than that of the native, and that the axial ligation of heme iron was changed to His71/His18 in the oxidized state, while to...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210782/ https://www.ncbi.nlm.nih.gov/pubmed/22087268 http://dx.doi.org/10.1371/journal.pone.0027219 |