Ethanol and Reactive Species Increase Basal Sequence Heterogeneity of Hepatitis C Virus and Produce Variants with Reduced Susceptibility to Antivirals

Hepatitis C virus (HCV) exhibits a high level of genetic variability, and variants with reduced susceptibility to antivirals can occur even before treatment begins. In addition, alcohol decreases efficacy of antiviral therapy and increases sequence heterogeneity of HCV RNA but how ethanol affects HC...

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Detalles Bibliográficos
Autores principales: Seronello, Scott, Montanez, Jessica, Presleigh, Kristen, Barlow, Miriam, Park, Seung Bum, Choi, Jinah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210796/
https://www.ncbi.nlm.nih.gov/pubmed/22087316
http://dx.doi.org/10.1371/journal.pone.0027436

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210796/
https://www.ncbi.nlm.nih.gov/pubmed/22087316
http://dx.doi.org/10.1371/journal.pone.0027436

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