DNA Damage Stress and Inhibition of Jak2-V617F Cause Its Degradation and Synergistically Induce Apoptosis through Activation of GSK3β

The cytoplasmic tyrosine kinase Jak2 plays a crucial role in cytokine receptor signaling in hematopoietic cells. The activated Jak2-V617F mutant is present in most cases of BCR/ABL-negative myeloproliferative neoplasms and constitutively activates downstream signals from homodimeric cytokine recepto...

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Detalles Bibliográficos
Autores principales: Nagao, Toshikage, Oshikawa, Gaku, Wu, Nan, Kurosu, Tetsuya, Miura, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210803/
https://www.ncbi.nlm.nih.gov/pubmed/22087308
http://dx.doi.org/10.1371/journal.pone.0027397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210803/
https://www.ncbi.nlm.nih.gov/pubmed/22087308
http://dx.doi.org/10.1371/journal.pone.0027397

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