Structural Features Determining the Intestinal Epithelial Permeability and Efflux of Novel HIV-1 Protease Inhibitors

The primary aim of this study was to identify structural features that alter the intestinal epithelial permeability and efflux in a series of novel HIV-1 protease inhibitors (PIs). Eleven PIs were selected containing a tertiary alcohol in a transition-state mimicking scaffold, in which two substitue...

Descripción completa

Detalles Bibliográficos
Autores principales: Lazorova, Lucia, Hubatsch, Ina, Ekegren, Jenny K, Gising, Johan, Nakai, Daisuke, Zaki, Noha M, Bergström, Christel A S, Norinder, Ulf, Larhed, Mats, Artursson, Per
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210832/
https://www.ncbi.nlm.nih.gov/pubmed/21491458
http://dx.doi.org/10.1002/jps.22570

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210832/
https://www.ncbi.nlm.nih.gov/pubmed/21491458
http://dx.doi.org/10.1002/jps.22570

Ejemplares similares