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Structural Features Determining the Intestinal Epithelial Permeability and Efflux of Novel HIV-1 Protease Inhibitors

The primary aim of this study was to identify structural features that alter the intestinal epithelial permeability and efflux in a series of novel HIV-1 protease inhibitors (PIs). Eleven PIs were selected containing a tertiary alcohol in a transition-state mimicking scaffold, in which two substitue...

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Detalles Bibliográficos
Autores principales:	Lazorova, Lucia, Hubatsch, Ina, Ekegren, Jenny K, Gising, Johan, Nakai, Daisuke, Zaki, Noha M, Bergström, Christel A S, Norinder, Ulf, Larhed, Mats, Artursson, Per
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wiley Subscription Services, Inc., A Wiley Company 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210832/ https://www.ncbi.nlm.nih.gov/pubmed/21491458 http://dx.doi.org/10.1002/jps.22570

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