Antibacterial Activity of New Dibenzoxepinone Oximes with Fluorine and Trifluoromethyl Group Substituents

In this paper we present the antimicrobial activity of some newly synthesized dibenz[b,e]oxepin derivatives bearing the oximino moiety, and fluorine (F) and trifluoromethyl (CF(3)) group substituents. The chemical structure and purity of the new compounds were assessed by using elemental analysis, N...

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Detalles Bibliográficos
Autores principales: Limban, Carmen, Chifiriuc, Mariana Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210988/
https://www.ncbi.nlm.nih.gov/pubmed/22072897
http://dx.doi.org/10.3390/ijms12106432
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author Limban, Carmen
Chifiriuc, Mariana Carmen
author_facet Limban, Carmen
Chifiriuc, Mariana Carmen
author_sort Limban, Carmen
collection PubMed
description In this paper we present the antimicrobial activity of some newly synthesized dibenz[b,e]oxepin derivatives bearing the oximino moiety, and fluorine (F) and trifluoromethyl (CF(3)) group substituents. The chemical structure and purity of the new compounds were assessed by using elemental analysis, NMR and FTIR spectroscopy. The new compounds were screened for their antibacterial activity towards Gram-positive and Gram-negative strains, by qualitative and quantitative assays. Our results demonstrated that the CF(3) and F disubstituted compounds could be considered for the further development of novel antimicrobial drugs.
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spelling pubmed-32109882011-11-09 Antibacterial Activity of New Dibenzoxepinone Oximes with Fluorine and Trifluoromethyl Group Substituents Limban, Carmen Chifiriuc, Mariana Carmen Int J Mol Sci Article In this paper we present the antimicrobial activity of some newly synthesized dibenz[b,e]oxepin derivatives bearing the oximino moiety, and fluorine (F) and trifluoromethyl (CF(3)) group substituents. The chemical structure and purity of the new compounds were assessed by using elemental analysis, NMR and FTIR spectroscopy. The new compounds were screened for their antibacterial activity towards Gram-positive and Gram-negative strains, by qualitative and quantitative assays. Our results demonstrated that the CF(3) and F disubstituted compounds could be considered for the further development of novel antimicrobial drugs. Molecular Diversity Preservation International (MDPI) 2011-09-28 /pmc/articles/PMC3210988/ /pubmed/22072897 http://dx.doi.org/10.3390/ijms12106432 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Limban, Carmen
Chifiriuc, Mariana Carmen
Antibacterial Activity of New Dibenzoxepinone Oximes with Fluorine and Trifluoromethyl Group Substituents
title Antibacterial Activity of New Dibenzoxepinone Oximes with Fluorine and Trifluoromethyl Group Substituents
title_full Antibacterial Activity of New Dibenzoxepinone Oximes with Fluorine and Trifluoromethyl Group Substituents
title_fullStr Antibacterial Activity of New Dibenzoxepinone Oximes with Fluorine and Trifluoromethyl Group Substituents
title_full_unstemmed Antibacterial Activity of New Dibenzoxepinone Oximes with Fluorine and Trifluoromethyl Group Substituents
title_short Antibacterial Activity of New Dibenzoxepinone Oximes with Fluorine and Trifluoromethyl Group Substituents
title_sort antibacterial activity of new dibenzoxepinone oximes with fluorine and trifluoromethyl group substituents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210988/
https://www.ncbi.nlm.nih.gov/pubmed/22072897
http://dx.doi.org/10.3390/ijms12106432
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