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Crystallization Study and Comparative in Vitro–in Vivo Hydrolysis of PLA Reinforcement Ligament

In the present work, the crystallization behavior and in vitro–in vivo hydrolysis rates of PLA absorbable reinforcement ligaments used in orthopaedics for the repair and reinforcement of articulation instabilities were studied. Tensile strength tests showed that this reinforcement ligament has simil...

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Autores principales: Beslikas, Theodore, Gigis, Ioannis, Goulios, Vasilios, Christoforides, John, Papageorgiou, George Z., Bikiaris, Dimitrios N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210997/
https://www.ncbi.nlm.nih.gov/pubmed/22072906
http://dx.doi.org/10.3390/ijms12106597
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author Beslikas, Theodore
Gigis, Ioannis
Goulios, Vasilios
Christoforides, John
Papageorgiou, George Z.
Bikiaris, Dimitrios N.
author_facet Beslikas, Theodore
Gigis, Ioannis
Goulios, Vasilios
Christoforides, John
Papageorgiou, George Z.
Bikiaris, Dimitrios N.
author_sort Beslikas, Theodore
collection PubMed
description In the present work, the crystallization behavior and in vitro–in vivo hydrolysis rates of PLA absorbable reinforcement ligaments used in orthopaedics for the repair and reinforcement of articulation instabilities were studied. Tensile strength tests showed that this reinforcement ligament has similar mechanical properties to Fascia Latta, which is an allograft sourced from the ilio-tibial band of the human body. The PLA reinforcement ligament is a semicrystalline material with a glass transition temperature around 61 °C and a melting point of ~178 °C. Dynamic crystallization revealed that, although the crystallization rates of the material are slow, they are faster than the often-reported PLA crystallization rates. Mass loss and molecular weight reduction measurements showed that in vitro hydrolysis at 50 °C initially takes place at a slow rate, which gets progressively higher after 30–40 days. As found from SEM micrographs, deterioration of the PLA fibers begins during this time. Furthermore, as found from in vivo hydrolysis in the human body, the PLA reinforcement ligament is fully biocompatible and after 6 months of implantation is completely covered with flesh. However, the observed hydrolysis rate from in vivo studies was slow due to high molecular weight and degree of crystallinity.
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spelling pubmed-32109972011-11-09 Crystallization Study and Comparative in Vitro–in Vivo Hydrolysis of PLA Reinforcement Ligament Beslikas, Theodore Gigis, Ioannis Goulios, Vasilios Christoforides, John Papageorgiou, George Z. Bikiaris, Dimitrios N. Int J Mol Sci Article In the present work, the crystallization behavior and in vitro–in vivo hydrolysis rates of PLA absorbable reinforcement ligaments used in orthopaedics for the repair and reinforcement of articulation instabilities were studied. Tensile strength tests showed that this reinforcement ligament has similar mechanical properties to Fascia Latta, which is an allograft sourced from the ilio-tibial band of the human body. The PLA reinforcement ligament is a semicrystalline material with a glass transition temperature around 61 °C and a melting point of ~178 °C. Dynamic crystallization revealed that, although the crystallization rates of the material are slow, they are faster than the often-reported PLA crystallization rates. Mass loss and molecular weight reduction measurements showed that in vitro hydrolysis at 50 °C initially takes place at a slow rate, which gets progressively higher after 30–40 days. As found from SEM micrographs, deterioration of the PLA fibers begins during this time. Furthermore, as found from in vivo hydrolysis in the human body, the PLA reinforcement ligament is fully biocompatible and after 6 months of implantation is completely covered with flesh. However, the observed hydrolysis rate from in vivo studies was slow due to high molecular weight and degree of crystallinity. Molecular Diversity Preservation International (MDPI) 2011-10-10 /pmc/articles/PMC3210997/ /pubmed/22072906 http://dx.doi.org/10.3390/ijms12106597 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Beslikas, Theodore
Gigis, Ioannis
Goulios, Vasilios
Christoforides, John
Papageorgiou, George Z.
Bikiaris, Dimitrios N.
Crystallization Study and Comparative in Vitro–in Vivo Hydrolysis of PLA Reinforcement Ligament
title Crystallization Study and Comparative in Vitro–in Vivo Hydrolysis of PLA Reinforcement Ligament
title_full Crystallization Study and Comparative in Vitro–in Vivo Hydrolysis of PLA Reinforcement Ligament
title_fullStr Crystallization Study and Comparative in Vitro–in Vivo Hydrolysis of PLA Reinforcement Ligament
title_full_unstemmed Crystallization Study and Comparative in Vitro–in Vivo Hydrolysis of PLA Reinforcement Ligament
title_short Crystallization Study and Comparative in Vitro–in Vivo Hydrolysis of PLA Reinforcement Ligament
title_sort crystallization study and comparative in vitro–in vivo hydrolysis of pla reinforcement ligament
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210997/
https://www.ncbi.nlm.nih.gov/pubmed/22072906
http://dx.doi.org/10.3390/ijms12106597
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