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Manganese Superoxide Dismutase: Guardian of the Powerhouse
The mitochondrion is vital for many metabolic pathways in the cell, contributing all or important constituent enzymes for diverse functions such as β-oxidation of fatty acids, the urea cycle, the citric acid cycle, and ATP synthesis. The mitochondrion is also a major site of reactive oxygen species...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3211030/ https://www.ncbi.nlm.nih.gov/pubmed/22072939 http://dx.doi.org/10.3390/ijms12107114 |
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author | Holley, Aaron K. Bakthavatchalu, Vasudevan Velez-Roman, Joyce M. St. Clair, Daret K. |
author_facet | Holley, Aaron K. Bakthavatchalu, Vasudevan Velez-Roman, Joyce M. St. Clair, Daret K. |
author_sort | Holley, Aaron K. |
collection | PubMed |
description | The mitochondrion is vital for many metabolic pathways in the cell, contributing all or important constituent enzymes for diverse functions such as β-oxidation of fatty acids, the urea cycle, the citric acid cycle, and ATP synthesis. The mitochondrion is also a major site of reactive oxygen species (ROS) production in the cell. Aberrant production of mitochondrial ROS can have dramatic effects on cellular function, in part, due to oxidative modification of key metabolic proteins localized in the mitochondrion. The cell is equipped with myriad antioxidant enzyme systems to combat deleterious ROS production in mitochondria, with the mitochondrial antioxidant enzyme manganese superoxide dismutase (MnSOD) acting as the chief ROS scavenging enzyme in the cell. Factors that affect the expression and/or the activity of MnSOD, resulting in diminished antioxidant capacity of the cell, can have extraordinary consequences on the overall health of the cell by altering mitochondrial metabolic function, leading to the development and progression of numerous diseases. A better understanding of the mechanisms by which MnSOD protects cells from the harmful effects of overproduction of ROS, in particular, the effects of ROS on mitochondrial metabolic enzymes, may contribute to the development of novel treatments for various diseases in which ROS are an important component. |
format | Online Article Text |
id | pubmed-3211030 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-32110302011-11-09 Manganese Superoxide Dismutase: Guardian of the Powerhouse Holley, Aaron K. Bakthavatchalu, Vasudevan Velez-Roman, Joyce M. St. Clair, Daret K. Int J Mol Sci Review The mitochondrion is vital for many metabolic pathways in the cell, contributing all or important constituent enzymes for diverse functions such as β-oxidation of fatty acids, the urea cycle, the citric acid cycle, and ATP synthesis. The mitochondrion is also a major site of reactive oxygen species (ROS) production in the cell. Aberrant production of mitochondrial ROS can have dramatic effects on cellular function, in part, due to oxidative modification of key metabolic proteins localized in the mitochondrion. The cell is equipped with myriad antioxidant enzyme systems to combat deleterious ROS production in mitochondria, with the mitochondrial antioxidant enzyme manganese superoxide dismutase (MnSOD) acting as the chief ROS scavenging enzyme in the cell. Factors that affect the expression and/or the activity of MnSOD, resulting in diminished antioxidant capacity of the cell, can have extraordinary consequences on the overall health of the cell by altering mitochondrial metabolic function, leading to the development and progression of numerous diseases. A better understanding of the mechanisms by which MnSOD protects cells from the harmful effects of overproduction of ROS, in particular, the effects of ROS on mitochondrial metabolic enzymes, may contribute to the development of novel treatments for various diseases in which ROS are an important component. Molecular Diversity Preservation International (MDPI) 2011-10-21 /pmc/articles/PMC3211030/ /pubmed/22072939 http://dx.doi.org/10.3390/ijms12107114 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Holley, Aaron K. Bakthavatchalu, Vasudevan Velez-Roman, Joyce M. St. Clair, Daret K. Manganese Superoxide Dismutase: Guardian of the Powerhouse |
title | Manganese Superoxide Dismutase: Guardian of the Powerhouse |
title_full | Manganese Superoxide Dismutase: Guardian of the Powerhouse |
title_fullStr | Manganese Superoxide Dismutase: Guardian of the Powerhouse |
title_full_unstemmed | Manganese Superoxide Dismutase: Guardian of the Powerhouse |
title_short | Manganese Superoxide Dismutase: Guardian of the Powerhouse |
title_sort | manganese superoxide dismutase: guardian of the powerhouse |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3211030/ https://www.ncbi.nlm.nih.gov/pubmed/22072939 http://dx.doi.org/10.3390/ijms12107114 |
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