Cargando…

The encapsulation effect of UV molecular absorbers into biocompatible lipid nanoparticles

The efficiency of a cosmetic product depends not only on the active ingredients, but also on the carrier system devoted to improve its bioavailability. This article aims to encapsulate two couples of UV molecular absorbers, with a blocking action on both UV-A and UV-B domains, into efficient lipid n...

Descripción completa

Detalles Bibliográficos
Autores principales: Lacatusu, Ioana, Badea, Nicoleta, Murariu, Alina, Meghea, Aurelia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212221/
https://www.ncbi.nlm.nih.gov/pubmed/21711592
http://dx.doi.org/10.1186/1556-276X-6-73
_version_ 1782215945963438080
author Lacatusu, Ioana
Badea, Nicoleta
Murariu, Alina
Meghea, Aurelia
author_facet Lacatusu, Ioana
Badea, Nicoleta
Murariu, Alina
Meghea, Aurelia
author_sort Lacatusu, Ioana
collection PubMed
description The efficiency of a cosmetic product depends not only on the active ingredients, but also on the carrier system devoted to improve its bioavailability. This article aims to encapsulate two couples of UV molecular absorbers, with a blocking action on both UV-A and UV-B domains, into efficient lipid nanoparticles. The effect of encapsulation on the specific properties such as sun protection factor and photostability behaviour has been demonstrated. The lipid nanoparticles with size range 30-350 nm and a polydispersity index between 0.217 and 0.244 are obtained using a modified high shear homogenisation method. The nanoparticles had spherical shapes with a single crystallisation form of lipid matrices characteristic for the least ordered crystal structure (α-form). The in vitro determination of photoprotection has led to high SPF ratings, with values of about 20, which assure a good photoprotection and filtering about 95% of UV radiation. The photoprotection effect after irradiation stage was observed to be increased more than twice compared to initial samples as a result of isomerisation phenomena. All the results have shown that good photoprotection effect and improved photostability could be obtained using such sunscreen couples, thus demonstrating that UV absorbers-solid lipid nanoparticles are promising carriers for cosmetic formulations.
format Online
Article
Text
id pubmed-3212221
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Springer
record_format MEDLINE/PubMed
spelling pubmed-32122212011-11-09 The encapsulation effect of UV molecular absorbers into biocompatible lipid nanoparticles Lacatusu, Ioana Badea, Nicoleta Murariu, Alina Meghea, Aurelia Nanoscale Res Lett Nano Express The efficiency of a cosmetic product depends not only on the active ingredients, but also on the carrier system devoted to improve its bioavailability. This article aims to encapsulate two couples of UV molecular absorbers, with a blocking action on both UV-A and UV-B domains, into efficient lipid nanoparticles. The effect of encapsulation on the specific properties such as sun protection factor and photostability behaviour has been demonstrated. The lipid nanoparticles with size range 30-350 nm and a polydispersity index between 0.217 and 0.244 are obtained using a modified high shear homogenisation method. The nanoparticles had spherical shapes with a single crystallisation form of lipid matrices characteristic for the least ordered crystal structure (α-form). The in vitro determination of photoprotection has led to high SPF ratings, with values of about 20, which assure a good photoprotection and filtering about 95% of UV radiation. The photoprotection effect after irradiation stage was observed to be increased more than twice compared to initial samples as a result of isomerisation phenomena. All the results have shown that good photoprotection effect and improved photostability could be obtained using such sunscreen couples, thus demonstrating that UV absorbers-solid lipid nanoparticles are promising carriers for cosmetic formulations. Springer 2011-01-12 /pmc/articles/PMC3212221/ /pubmed/21711592 http://dx.doi.org/10.1186/1556-276X-6-73 Text en Copyright ©2011 Lacatusu et al; licensee Springer. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Nano Express
Lacatusu, Ioana
Badea, Nicoleta
Murariu, Alina
Meghea, Aurelia
The encapsulation effect of UV molecular absorbers into biocompatible lipid nanoparticles
title The encapsulation effect of UV molecular absorbers into biocompatible lipid nanoparticles
title_full The encapsulation effect of UV molecular absorbers into biocompatible lipid nanoparticles
title_fullStr The encapsulation effect of UV molecular absorbers into biocompatible lipid nanoparticles
title_full_unstemmed The encapsulation effect of UV molecular absorbers into biocompatible lipid nanoparticles
title_short The encapsulation effect of UV molecular absorbers into biocompatible lipid nanoparticles
title_sort encapsulation effect of uv molecular absorbers into biocompatible lipid nanoparticles
topic Nano Express
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212221/
https://www.ncbi.nlm.nih.gov/pubmed/21711592
http://dx.doi.org/10.1186/1556-276X-6-73
work_keys_str_mv AT lacatusuioana theencapsulationeffectofuvmolecularabsorbersintobiocompatiblelipidnanoparticles
AT badeanicoleta theencapsulationeffectofuvmolecularabsorbersintobiocompatiblelipidnanoparticles
AT murariualina theencapsulationeffectofuvmolecularabsorbersintobiocompatiblelipidnanoparticles
AT megheaaurelia theencapsulationeffectofuvmolecularabsorbersintobiocompatiblelipidnanoparticles
AT lacatusuioana encapsulationeffectofuvmolecularabsorbersintobiocompatiblelipidnanoparticles
AT badeanicoleta encapsulationeffectofuvmolecularabsorbersintobiocompatiblelipidnanoparticles
AT murariualina encapsulationeffectofuvmolecularabsorbersintobiocompatiblelipidnanoparticles
AT megheaaurelia encapsulationeffectofuvmolecularabsorbersintobiocompatiblelipidnanoparticles