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The encapsulation effect of UV molecular absorbers into biocompatible lipid nanoparticles
The efficiency of a cosmetic product depends not only on the active ingredients, but also on the carrier system devoted to improve its bioavailability. This article aims to encapsulate two couples of UV molecular absorbers, with a blocking action on both UV-A and UV-B domains, into efficient lipid n...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212221/ https://www.ncbi.nlm.nih.gov/pubmed/21711592 http://dx.doi.org/10.1186/1556-276X-6-73 |
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author | Lacatusu, Ioana Badea, Nicoleta Murariu, Alina Meghea, Aurelia |
author_facet | Lacatusu, Ioana Badea, Nicoleta Murariu, Alina Meghea, Aurelia |
author_sort | Lacatusu, Ioana |
collection | PubMed |
description | The efficiency of a cosmetic product depends not only on the active ingredients, but also on the carrier system devoted to improve its bioavailability. This article aims to encapsulate two couples of UV molecular absorbers, with a blocking action on both UV-A and UV-B domains, into efficient lipid nanoparticles. The effect of encapsulation on the specific properties such as sun protection factor and photostability behaviour has been demonstrated. The lipid nanoparticles with size range 30-350 nm and a polydispersity index between 0.217 and 0.244 are obtained using a modified high shear homogenisation method. The nanoparticles had spherical shapes with a single crystallisation form of lipid matrices characteristic for the least ordered crystal structure (α-form). The in vitro determination of photoprotection has led to high SPF ratings, with values of about 20, which assure a good photoprotection and filtering about 95% of UV radiation. The photoprotection effect after irradiation stage was observed to be increased more than twice compared to initial samples as a result of isomerisation phenomena. All the results have shown that good photoprotection effect and improved photostability could be obtained using such sunscreen couples, thus demonstrating that UV absorbers-solid lipid nanoparticles are promising carriers for cosmetic formulations. |
format | Online Article Text |
id | pubmed-3212221 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Springer |
record_format | MEDLINE/PubMed |
spelling | pubmed-32122212011-11-09 The encapsulation effect of UV molecular absorbers into biocompatible lipid nanoparticles Lacatusu, Ioana Badea, Nicoleta Murariu, Alina Meghea, Aurelia Nanoscale Res Lett Nano Express The efficiency of a cosmetic product depends not only on the active ingredients, but also on the carrier system devoted to improve its bioavailability. This article aims to encapsulate two couples of UV molecular absorbers, with a blocking action on both UV-A and UV-B domains, into efficient lipid nanoparticles. The effect of encapsulation on the specific properties such as sun protection factor and photostability behaviour has been demonstrated. The lipid nanoparticles with size range 30-350 nm and a polydispersity index between 0.217 and 0.244 are obtained using a modified high shear homogenisation method. The nanoparticles had spherical shapes with a single crystallisation form of lipid matrices characteristic for the least ordered crystal structure (α-form). The in vitro determination of photoprotection has led to high SPF ratings, with values of about 20, which assure a good photoprotection and filtering about 95% of UV radiation. The photoprotection effect after irradiation stage was observed to be increased more than twice compared to initial samples as a result of isomerisation phenomena. All the results have shown that good photoprotection effect and improved photostability could be obtained using such sunscreen couples, thus demonstrating that UV absorbers-solid lipid nanoparticles are promising carriers for cosmetic formulations. Springer 2011-01-12 /pmc/articles/PMC3212221/ /pubmed/21711592 http://dx.doi.org/10.1186/1556-276X-6-73 Text en Copyright ©2011 Lacatusu et al; licensee Springer. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Nano Express Lacatusu, Ioana Badea, Nicoleta Murariu, Alina Meghea, Aurelia The encapsulation effect of UV molecular absorbers into biocompatible lipid nanoparticles |
title | The encapsulation effect of UV molecular absorbers into biocompatible lipid nanoparticles |
title_full | The encapsulation effect of UV molecular absorbers into biocompatible lipid nanoparticles |
title_fullStr | The encapsulation effect of UV molecular absorbers into biocompatible lipid nanoparticles |
title_full_unstemmed | The encapsulation effect of UV molecular absorbers into biocompatible lipid nanoparticles |
title_short | The encapsulation effect of UV molecular absorbers into biocompatible lipid nanoparticles |
title_sort | encapsulation effect of uv molecular absorbers into biocompatible lipid nanoparticles |
topic | Nano Express |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212221/ https://www.ncbi.nlm.nih.gov/pubmed/21711592 http://dx.doi.org/10.1186/1556-276X-6-73 |
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