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2-Hydroxy-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione
The seven-membered ring of the title compound, C(12)H(12)N(2)O(3), which is fused with the phenylene ring, adopts a boat-shaped conformation (with the methine C atom as the prow and the phenylene C atoms as the stern); the H atom on the methine linkage exists in an axial position. The five-membere...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212299/ https://www.ncbi.nlm.nih.gov/pubmed/22090956 http://dx.doi.org/10.1107/S1600536811025244 |
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author | Ourahou, Sarah Zouihri, Hafid Massoui, Mohamed Essassi, El Mokhtar Ng, Seik Weng |
author_facet | Ourahou, Sarah Zouihri, Hafid Massoui, Mohamed Essassi, El Mokhtar Ng, Seik Weng |
author_sort | Ourahou, Sarah |
collection | PubMed |
description | The seven-membered ring of the title compound, C(12)H(12)N(2)O(3), which is fused with the phenylene ring, adopts a boat-shaped conformation (with the methine C atom as the prow and the phenylene C atoms as the stern); the H atom on the methine linkage exists in an axial position. The five-membered ring that is fused with the seven-membered ring adopts an envelope conformation (with the C atom bearing the hydroxy substituent representing the flap) [the deviation from the plane defined by the other four atoms is 0.200 (7) Å in one molecule and 0.627 (5) Å in the other]. The two independent molecules are disposed about a pseudo center of inversion and are connected by a pair of N—H⋯O hydrogen bonds. Adjacent dimers are linked by a pair of O—H⋯O hydrogen bonds, generating a chain running along the b axis. |
format | Online Article Text |
id | pubmed-3212299 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-32122992011-11-16 2-Hydroxy-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione Ourahou, Sarah Zouihri, Hafid Massoui, Mohamed Essassi, El Mokhtar Ng, Seik Weng Acta Crystallogr Sect E Struct Rep Online Organic Papers The seven-membered ring of the title compound, C(12)H(12)N(2)O(3), which is fused with the phenylene ring, adopts a boat-shaped conformation (with the methine C atom as the prow and the phenylene C atoms as the stern); the H atom on the methine linkage exists in an axial position. The five-membered ring that is fused with the seven-membered ring adopts an envelope conformation (with the C atom bearing the hydroxy substituent representing the flap) [the deviation from the plane defined by the other four atoms is 0.200 (7) Å in one molecule and 0.627 (5) Å in the other]. The two independent molecules are disposed about a pseudo center of inversion and are connected by a pair of N—H⋯O hydrogen bonds. Adjacent dimers are linked by a pair of O—H⋯O hydrogen bonds, generating a chain running along the b axis. International Union of Crystallography 2011-07-06 /pmc/articles/PMC3212299/ /pubmed/22090956 http://dx.doi.org/10.1107/S1600536811025244 Text en © Ourahou et al. 2011 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
spellingShingle | Organic Papers Ourahou, Sarah Zouihri, Hafid Massoui, Mohamed Essassi, El Mokhtar Ng, Seik Weng 2-Hydroxy-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione |
title | 2-Hydroxy-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione |
title_full | 2-Hydroxy-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione |
title_fullStr | 2-Hydroxy-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione |
title_full_unstemmed | 2-Hydroxy-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione |
title_short | 2-Hydroxy-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione |
title_sort | 2-hydroxy-2,3,5,10,11,11a-hexahydro-1h-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione |
topic | Organic Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212299/ https://www.ncbi.nlm.nih.gov/pubmed/22090956 http://dx.doi.org/10.1107/S1600536811025244 |
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