Cargando…

Leoligin, the major lignan from Edelweiss, activates cholesteryl ester transfer protein

OBJECTIVE: Cholesteryl ester transfer protein (CETP) plays a central role in the metabolism of high-density lipoprotein particles. Therefore, we searched for new drugs that bind to CETP and modulate its activity. METHODS: A preliminary pharmacophore-based parallel screening approach indicated that l...

Descripción completa

Detalles Bibliográficos
Autores principales:	Duwensee, Kristina, Schwaiger, Stefan, Tancevski, Ivan, Eller, Kathrin, van Eck, Miranda, Markt, Patrick, Linder, Tobias, Stanzl, Ursula, Ritsch, Andreas, Patsch, Josef R., Schuster, Daniela, Stuppner, Hermann, Bernhard, David, Eller, Philipp
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212649/ https://www.ncbi.nlm.nih.gov/pubmed/21820657 http://dx.doi.org/10.1016/j.atherosclerosis.2011.07.023

Ejemplares similares

Leoligin, the major lignan from Edelweiss, inhibits intimal hyperplasia of venous bypass grafts
por: Reisinger, Ute, et al.
Publicado: (2009)

Leoligin, the Major Lignan from Edelweiss (Leontopodium nivale subsp. alpinum), Promotes Cholesterol Efflux from THP-1 Macrophages
por: Wang, Limei, et al.
Publicado: (2016)

Leoligin-inspired synthetic lignans with selectivity for cell-type and bioactivity relevant for cardiovascular disease
por: Linder, Thomas, et al.
Publicado: (2019)

Lignan formation in hairy root cultures of Edelweiss (Leontopodium nivale ssp. alpinum (Cass.) Greuter)
por: Wawrosch, Christoph, et al.
Publicado: (2014)

Inhibition of hepatic scavenger receptor-class B type I by RNA interference decreases atherosclerosis in rabbits
por: Demetz, Egon, et al.
Publicado: (2012)

5-Methoxyleoligin, a Lignan from Edelweiss, Stimulates CYP26B1-Dependent Angiogenesis In Vitro and Induces Arteriogenesis in Infarcted Rat Hearts In Vivo
por: Messner, Barbara, et al.
Publicado: (2013)

The Liver-Selective Thyromimetic T-0681 Influences Reverse Cholesterol Transport and Atherosclerosis Development in Mice
por: Tancevski, Ivan, et al.
Publicado: (2010)

Edelweiss
por: Gerbier, Gilles
Publicado: (2011)

Interaction of Carthamus tinctorius lignan arctigenin with the binding site of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase()
por: Temml, Veronika, et al.
Publicado: (2013)

Potential Role of Regulatory T Cells in Reversing Obesity-Linked Insulin Resistance and Diabetic Nephropathy
por: Eller, Kathrin, et al.
Publicado: (2011)

Investigation of Leoligin Derivatives as NF-κΒ Inhibitory Agents
por: Linder, Thomas, et al.
Publicado: (2021)

Quantitative analysis of anti-inflammatory lignan derivatives in Ratanhiae radix and its tincture by HPLC–PDA and HPLC–MS
por: Baumgartner, Lisa, et al.
Publicado: (2011)

Status of the EDELWEISS experiment
por: De Jésus, M, et al.
Publicado: (2000)

Ernst Fuchs: Edelweiss of Ophthalmology
por: Sen, Mrittika, et al.
Publicado: (2021)

The EDELWEISS experiment: a status report
por: Yvon, D, et al.
Publicado: (1995)

Cholesteryl ester transfer protein: at the heart of the action of lipid-modulating therapy with statins, fibrates, niacin, and cholesteryl ester transfer protein inhibitors
por: Chapman, M. John, et al.
Publicado: (2010)

Assessing the mechanisms of cholesteryl ester transfer protein inhibitors
por: Zhang, Meng, et al.
Publicado: (2017)

Latest results from the EDELWEISS WIMP search
por: Chardin, G, et al.
Publicado: (2003)

Neutron background studies for the EDELWEISS WIMP search
por: Chardin, G, et al.
Publicado: (2003)

Concentration dependent cholesteryl-ester and wax-ester structural relationships and meibomian gland dysfunction
por: Hetman, Zofia A., et al.
Publicado: (2020)

Reversible accumulation of cholesteryl esters in macrophages incubated with acetylated lipoproteins
Publicado: (1979)

Cholesteryl ester transfer protein inhibitors for dyslipidemia: focus on dalcetrapib
por: Goldberg, Alyse S, et al.
Publicado: (2012)

Cholesteryl Ester Transfer Protein Gene Polymorphisms and Longevity Syndrome
por: Kolovou, Genovefa, et al.
Publicado: (2010)

Cholesteryl Ester Transfer Protein (CETP) Deficiency and CETP Inhibitors
por: Mabuchi, Hiroshi, et al.
Publicado: (2014)

Fluorescent Sterols and Cholesteryl Esters as Probes for Intracellular Cholesterol Transport
por: Solanko, Katarzyna A., et al.
Publicado: (2016)

Structure-based mechanism and inhibition of cholesteryl ester transfer protein
por: Xue, Han, et al.
Publicado: (2023)

Cholesteryl Ester Transfer Protein Gene and Effectiveness of Lipid Lowering of Atorvastatin
por: Kolovou, Genovefa, et al.
Publicado: (2010)

Cholesteryl Esters Accumulate in the Heart in a Porcine Model of Ischemia and Reperfusion
por: Drevinge, Christina, et al.
Publicado: (2013)

The Proteome of Cholesteryl-Ester-Enriched Versus Triacylglycerol-Enriched Lipid Droplets
por: Khor, Victor K., et al.
Publicado: (2014)

Cholesteryl ester transfer protein: ace of spades, queen of hearts, or the joker?
por: Miller, Norman E.
Publicado: (2015)

REVEAL Study: Reveals the Limitations of Cholesteryl Ester Transfer Protein Inhibition
por: Pareek, Anil, et al.
Publicado: (2018)

Cholesterol is Inefficiently Converted to Cholesteryl Esters in the Blood of Cardiovascular Disease Patients
por: Gerl, Mathias J., et al.
Publicado: (2018)

Cholesteryl ester levels are elevated in the caudate and putamen of Huntington’s disease patients
por: Phillips, Gabrielle R., et al.
Publicado: (2020)

Correlation of cholesteryl ester metabolism to pathogenesis, progression and disparities in colorectal Cancer
por: Liu, Zhirong, et al.
Publicado: (2022)

The cholesteryl ester transfer protein (CETP) raises cholesterol levels in the brain
por: Oestereich, Felix, et al.
Publicado: (2022)

Hepatocyte-specific deletion of lysosomal acid lipase leads to cholesteryl ester but not triglyceride or retinyl ester accumulation
por: Pajed, Laura, et al.
Publicado: (2019)

Morphological characterization of the cholesteryl ester cycle in cultured mouse macrophage foam cells
Publicado: (1983)

Evolving neural network optimization of cholesteryl ester separation by reversed-phase HPLC
por: Jansen, Michael A., et al.
Publicado: (2010)

Cholesteryl ester transfer-protein modulator and inhibitors and their potential for the treatment of cardiovascular diseases
por: Shinkai, Hisashi
Publicado: (2012)

The effect of cholesteryl ester transfer protein on pancreatic beta cell dysfunction in mice
por: Guo, Wen, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_03e794gtv20nhct8uh2cs52hhq