The coumarin scopoletin potentiates acetylcholine release from synaptosomes, amplifies hippocampal long-term potentiation and ameliorates anticholinergic- and age-impaired memory

In a previous study the simple, naturally derived coumarin scopoletin (SCT) was identified as an inhibitor of acetylcholinesterase (AChE), using a pharmacophore-based virtual screening approach. In this study the potential of SCT as procholinergic and cognition-enhancing therapeutic was investigated...

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Detalles Bibliográficos
Autores principales: Hornick, A., Lieb, A., Vo, N.P., Rollinger, J.M., Stuppner, H., Prast, H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2011
Materias:
Cognitive, Behavioral, and Systems Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212650/
https://www.ncbi.nlm.nih.gov/pubmed/21945033
http://dx.doi.org/10.1016/j.neuroscience.2011.09.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212650/
https://www.ncbi.nlm.nih.gov/pubmed/21945033
http://dx.doi.org/10.1016/j.neuroscience.2011.09.006

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