Non-Viral Causes of Hepatocellular Carcinoma

INTRODUCTION: Hepatocellular carcinoma (HCC) is a major cause of cancer worldwide. The vast majority of cases occur in individuals with a chronic HBV or HCV infection. In addition, a number of metabolic diseases of the liver are associated with the development of HCC. PATHOPHYSIOLOGIC MECHANISMS: Th...

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Detalles Bibliográficos
Autores principales: Van Thiel, David H., Ramadori, Guiliano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2010
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212675/
https://www.ncbi.nlm.nih.gov/pubmed/20820946
http://dx.doi.org/10.1007/s12029-010-9195-3
Descripción
Sumario:INTRODUCTION: Hepatocellular carcinoma (HCC) is a major cause of cancer worldwide. The vast majority of cases occur in individuals with a chronic HBV or HCV infection. In addition, a number of metabolic diseases of the liver are associated with the development of HCC. PATHOPHYSIOLOGIC MECHANISMS: The mechanisms responsible for the progression of the metabolic liver disease and HCC differ from those associated with viral liver disease. CONCLUSIONS: The purpose of this report is to describe the mechanisms responsible for the disease progression and HCC in case of metabolic liver disease. A secondary goal is to identify the frequency of HCC development in the disorders described.

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