Improvement of Sodium Status to Optimize the Efficacy of Renin-Angiotensin System Blockade

Blockade of the renin-angiotensin-aldosterone system (RAAS) offers superior renoprotection in the treatment of patients with hypertension, but the efficacy of RAAS inhibition strongly depends on sodium status, presumably in relation to extracellular volume status. Because assessing volume status by...

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Detalles Bibliográficos
Autores principales: Laverman, Gozewijn D., Navis, Gerjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Current Science Inc. 2011
Materias:
Invited Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212696/
https://www.ncbi.nlm.nih.gov/pubmed/21964882
http://dx.doi.org/10.1007/s11906-011-0234-7
Descripción
Sumario:Blockade of the renin-angiotensin-aldosterone system (RAAS) offers superior renoprotection in the treatment of patients with hypertension, but the efficacy of RAAS inhibition strongly depends on sodium status, presumably in relation to extracellular volume status. Because assessing volume status by physical examination is challenging, 24-hour urine collection and NT-proBNP levels are useful tools for guiding volume management and achieving sodium status targets.

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