Cargando…
Polymorphisms of methylenetetrahydrofolate reductase are not a risk factor for Kawasaki disease in the Korean population
PURPOSE: Hyperhomocysteinemia is known as a risk factor for atherosclerosis. Preclinical arteriosclerosis is noted and premature atherosclerosis is known to be accelerated in Kawasaki disease (KD) patients. Genetic polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene result in...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Pediatric Society
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212703/ https://www.ncbi.nlm.nih.gov/pubmed/22087200 http://dx.doi.org/10.3345/kjp.2011.54.8.335 |
_version_ | 1782216011445960704 |
---|---|
author | Yoon, Kyung Lim Ko, Jin Hee Shim, Kye Shik Han, Mi Young Cha, Sung Ho Kim, Su Kang Jung, Joo Ho |
author_facet | Yoon, Kyung Lim Ko, Jin Hee Shim, Kye Shik Han, Mi Young Cha, Sung Ho Kim, Su Kang Jung, Joo Ho |
author_sort | Yoon, Kyung Lim |
collection | PubMed |
description | PURPOSE: Hyperhomocysteinemia is known as a risk factor for atherosclerosis. Preclinical arteriosclerosis is noted and premature atherosclerosis is known to be accelerated in Kawasaki disease (KD) patients. Genetic polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene result in elevated plasma homocysteine concentrations and are known to be associated with the development of coronary artery disease. Our hypothesis is that single nucleotide polymorphisms (SNPs) of the MTHFR gene are related to the development of KD and coronary artery lesions (CALs). METHODS: For this study, we selected 3 candidate single nucleotide polymorphisms (SNPs) (rs2274976, rs1801131, and rs1801133) of MTHFR. These SNPs are located on chromosome 1p36.3. We included 101 KD patients and 306 healthy adults as controls in this study. CALs were seen in 38 patients. Genotypes of the selected SNPs were determined by direct sequencing and analyzed with SNPAlyze. RESULTS: The genetic distribution and allelic frequency of the 3 MTHFR SNPs (rs2274976, rs1801131, and rs1801133) were not significantly different in patients with KD compared to the control group (P=0.71, 0.17, and 0.96, respectively). There was no difference in the genetic distribution of the MTHFR SNPs between the normal control group and the CAL group (P=0.43, 0.39, 0.52 respectively). CONCLUSION: The genetic distribution of the MTHFR SNPs (rs2274976, rs1801131, and rs1801133) was not different in the KD group compared to the control group. In addition, the genetic distribution of these SNPs was not different in the CAL group compared to the control group in the Korean population. |
format | Online Article Text |
id | pubmed-3212703 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | The Korean Pediatric Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-32127032011-11-15 Polymorphisms of methylenetetrahydrofolate reductase are not a risk factor for Kawasaki disease in the Korean population Yoon, Kyung Lim Ko, Jin Hee Shim, Kye Shik Han, Mi Young Cha, Sung Ho Kim, Su Kang Jung, Joo Ho Korean J Pediatr Original Article PURPOSE: Hyperhomocysteinemia is known as a risk factor for atherosclerosis. Preclinical arteriosclerosis is noted and premature atherosclerosis is known to be accelerated in Kawasaki disease (KD) patients. Genetic polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene result in elevated plasma homocysteine concentrations and are known to be associated with the development of coronary artery disease. Our hypothesis is that single nucleotide polymorphisms (SNPs) of the MTHFR gene are related to the development of KD and coronary artery lesions (CALs). METHODS: For this study, we selected 3 candidate single nucleotide polymorphisms (SNPs) (rs2274976, rs1801131, and rs1801133) of MTHFR. These SNPs are located on chromosome 1p36.3. We included 101 KD patients and 306 healthy adults as controls in this study. CALs were seen in 38 patients. Genotypes of the selected SNPs were determined by direct sequencing and analyzed with SNPAlyze. RESULTS: The genetic distribution and allelic frequency of the 3 MTHFR SNPs (rs2274976, rs1801131, and rs1801133) were not significantly different in patients with KD compared to the control group (P=0.71, 0.17, and 0.96, respectively). There was no difference in the genetic distribution of the MTHFR SNPs between the normal control group and the CAL group (P=0.43, 0.39, 0.52 respectively). CONCLUSION: The genetic distribution of the MTHFR SNPs (rs2274976, rs1801131, and rs1801133) was not different in the KD group compared to the control group. In addition, the genetic distribution of these SNPs was not different in the CAL group compared to the control group in the Korean population. The Korean Pediatric Society 2011-08 2011-08-31 /pmc/articles/PMC3212703/ /pubmed/22087200 http://dx.doi.org/10.3345/kjp.2011.54.8.335 Text en Copyright © 2011 by The Korean Pediatric Society http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Yoon, Kyung Lim Ko, Jin Hee Shim, Kye Shik Han, Mi Young Cha, Sung Ho Kim, Su Kang Jung, Joo Ho Polymorphisms of methylenetetrahydrofolate reductase are not a risk factor for Kawasaki disease in the Korean population |
title | Polymorphisms of methylenetetrahydrofolate reductase are not a risk factor for Kawasaki disease in the Korean population |
title_full | Polymorphisms of methylenetetrahydrofolate reductase are not a risk factor for Kawasaki disease in the Korean population |
title_fullStr | Polymorphisms of methylenetetrahydrofolate reductase are not a risk factor for Kawasaki disease in the Korean population |
title_full_unstemmed | Polymorphisms of methylenetetrahydrofolate reductase are not a risk factor for Kawasaki disease in the Korean population |
title_short | Polymorphisms of methylenetetrahydrofolate reductase are not a risk factor for Kawasaki disease in the Korean population |
title_sort | polymorphisms of methylenetetrahydrofolate reductase are not a risk factor for kawasaki disease in the korean population |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212703/ https://www.ncbi.nlm.nih.gov/pubmed/22087200 http://dx.doi.org/10.3345/kjp.2011.54.8.335 |
work_keys_str_mv | AT yoonkyunglim polymorphismsofmethylenetetrahydrofolatereductasearenotariskfactorforkawasakidiseaseinthekoreanpopulation AT kojinhee polymorphismsofmethylenetetrahydrofolatereductasearenotariskfactorforkawasakidiseaseinthekoreanpopulation AT shimkyeshik polymorphismsofmethylenetetrahydrofolatereductasearenotariskfactorforkawasakidiseaseinthekoreanpopulation AT hanmiyoung polymorphismsofmethylenetetrahydrofolatereductasearenotariskfactorforkawasakidiseaseinthekoreanpopulation AT chasungho polymorphismsofmethylenetetrahydrofolatereductasearenotariskfactorforkawasakidiseaseinthekoreanpopulation AT kimsukang polymorphismsofmethylenetetrahydrofolatereductasearenotariskfactorforkawasakidiseaseinthekoreanpopulation AT jungjooho polymorphismsofmethylenetetrahydrofolatereductasearenotariskfactorforkawasakidiseaseinthekoreanpopulation |