ATRA Induced Reactive Hemophagocytosis: a Case Report

All trans-retinoic acid (ATRA) is a targeted therapy, used in Acute Promyelcytic leukemia (APL) and causes the abnormal promyelocytes to differentiate in to mature leucocytes, however their clearance in vivo is not known. ATRA has been found to be associated with hemophagocytosis, but sometimes one...

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Detalles Bibliográficos
Autores principales: Sharma, Monica, Dass, Jasmita, Tyagi, Seema
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Università Cattolica del Sacro Cuore 2011
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212967/
https://www.ncbi.nlm.nih.gov/pubmed/22084649
http://dx.doi.org/10.4084/MJHID.2011.034
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author Sharma, Monica
Dass, Jasmita
Tyagi, Seema
author_facet Sharma, Monica
Dass, Jasmita
Tyagi, Seema
author_sort Sharma, Monica
collection PubMed
description All trans-retinoic acid (ATRA) is a targeted therapy, used in Acute Promyelcytic leukemia (APL) and causes the abnormal promyelocytes to differentiate in to mature leucocytes, however their clearance in vivo is not known. ATRA has been found to be associated with hemophagocytosis, but sometimes one may find phagocytosis of differentiated cells by histiocytes without the overt manifestations of hemophagocytic syndrome. We report a case of APL showing differentiated cells being phagocytosed by marrow histiocytes while patient was getting ATRA therapy.
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spelling pubmed-32129672011-11-14 ATRA Induced Reactive Hemophagocytosis: a Case Report Sharma, Monica Dass, Jasmita Tyagi, Seema Mediterr J Hematol Infect Dis Case Reports All trans-retinoic acid (ATRA) is a targeted therapy, used in Acute Promyelcytic leukemia (APL) and causes the abnormal promyelocytes to differentiate in to mature leucocytes, however their clearance in vivo is not known. ATRA has been found to be associated with hemophagocytosis, but sometimes one may find phagocytosis of differentiated cells by histiocytes without the overt manifestations of hemophagocytic syndrome. We report a case of APL showing differentiated cells being phagocytosed by marrow histiocytes while patient was getting ATRA therapy. Università Cattolica del Sacro Cuore 2011-09-08 /pmc/articles/PMC3212967/ /pubmed/22084649 http://dx.doi.org/10.4084/MJHID.2011.034 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Sharma, Monica
Dass, Jasmita
Tyagi, Seema
ATRA Induced Reactive Hemophagocytosis: a Case Report
title ATRA Induced Reactive Hemophagocytosis: a Case Report
title_full ATRA Induced Reactive Hemophagocytosis: a Case Report
title_fullStr ATRA Induced Reactive Hemophagocytosis: a Case Report
title_full_unstemmed ATRA Induced Reactive Hemophagocytosis: a Case Report
title_short ATRA Induced Reactive Hemophagocytosis: a Case Report
title_sort atra induced reactive hemophagocytosis: a case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212967/
https://www.ncbi.nlm.nih.gov/pubmed/22084649
http://dx.doi.org/10.4084/MJHID.2011.034
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AT dassjasmita atrainducedreactivehemophagocytosisacasereport
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