Cargando…

Murine Gamma Herpesvirus 68 Hijacks MAVS and IKKβ to Abrogate NFκB Activation and Antiviral Cytokine Production

Upon viral infection, mitochondrial antiviral signaling (MAVS) protein serves as a key adaptor to promote cytokine production. We report here that murine gamma herpesvirus 68 (γHV68), a model virus for oncogenic human gamma herpesviruses, subverts cytokine production via the MAVS adaptor. During ear...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dong, Xiaonan, Feng, Pinghui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213086/ https://www.ncbi.nlm.nih.gov/pubmed/22110409 http://dx.doi.org/10.1371/journal.ppat.1002336

Ejemplares similares

Murine Gamma-Herpesvirus 68 Hijacks MAVS and IKKβ to Initiate Lytic Replication
por: Dong, Xiaonan, et al.
Publicado: (2010)

Recombinant Murine Gamma Herpesvirus 68 Carrying KSHV G Protein-Coupled Receptor Induces Angiogenic Lesions in Mice
por: Zhang, Junjie, et al.
Publicado: (2015)

M1 of Murine Gamma-Herpesvirus 68 Induces Endoplasmic Reticulum Chaperone Production
por: Feng, Jiaying, et al.
Publicado: (2015)

Dengue Virus 2 NS2B Targets MAVS and IKKε to Evade the Antiviral Innate Immune Response
por: Nie, Ying, et al.
Publicado: (2023)

IgG Fc Receptors Provide an Alternative Infection Route for Murine Gamma-Herpesvirus-68
por: Rosa, Gustavo T., et al.
Publicado: (2007)

Inhibition of murine herpesvirus-68 replication by IFN-gamma in macrophages is counteracted by the induction of SOCS1 expression
por: Shen, Yong, et al.
Publicado: (2018)

Antiviral Adaptor MAVS Promotes Murine Lupus With a B Cell Autonomous Role
por: Sun, Wenxiang, et al.
Publicado: (2019)

MAVS activates TBK1 and IKKε through TRAFs in NEMO dependent and independent manner
por: Fang, Run, et al.
Publicado: (2017)

PPM1G restricts innate immune signaling mediated by STING and MAVS and is hijacked by KSHV for immune evasion
por: Yu, Kuai, et al.
Publicado: (2020)

CELLULAR RNA INTERACTS WITH MAVS TO PROMOTE ANTIVIRAL SIGNALING
por: Gokhale, Nandan S., et al.
Publicado: (2023)

TfR1 interacts with the IKK complex and is involved in IKK–NF-κB signalling
por: Kenneth, Niall S., et al.
Publicado: (2012)

The IKK Kinases: Operators of Antiviral Signaling
por: Pham, Alissa M., et al.
Publicado: (2010)

Regulation of MDA5-MAVS Antiviral Signaling Axis by TRIM25 through TRAF6-Mediated NF-κB Activation
por: Lee, Na-Rae, et al.
Publicado: (2015)

IKKβ/NF-κB and the miscreant macrophage
por: Timmer, Anjuli M., et al.
Publicado: (2008)

Human Herpesvirus 6B U26 Inhibits the Activation of the RLR/MAVS Signaling Pathway
por: Jiang, Xuefeng, et al.
Publicado: (2021)

Inhibition of Osteoblast Functions by IKK/NF-κB in Osteoporosis
por: Chang, Jia, et al.
Publicado: (2009)

Regional Susceptibility to TNF-α Induction of Murine Brain Inflammation via Classical IKK/NF-κB Signalling
por: Young, Adam M. H., et al.
Publicado: (2012)

Herpesvirus Telomerase RNA (vTR) with a Mutated Template Sequence Abrogates Herpesvirus-Induced Lymphomagenesis
por: Kaufer, Benedikt B., et al.
Publicado: (2011)

Structural basis for the prion-like MAVS filaments in antiviral innate immunity
por: Xu, Hui, et al.
Publicado: (2014)

An autoinhibitory mechanism modulates MAVS activity in antiviral innate immune response
por: Shi, Yuheng, et al.
Publicado: (2015)

Regulation of MAVS Expression and Signaling Function in the Antiviral Innate Immune Response
por: Ren, Zhihua, et al.
Publicado: (2020)

Succinate Is a Natural Suppressor of Antiviral Immune Response by Targeting MAVS
por: Xiao, Yue, et al.
Publicado: (2022)

Alteration of Antiviral Signalling by Single Nucleotide Polymorphisms (SNPs) of Mitochondrial Antiviral Signalling Protein (MAVS)
por: Xing, Fei, et al.
Publicado: (2016)

Penaeus monodon IKKs Participate in Regulation of Cytokine-Like System and Antiviral Responses of Innate Immune System
por: Nhnhkorn, Zittipong, et al.
Publicado: (2019)

Oncogenic Herpesvirus KSHV Hijacks BMP-Smad1-Id Signaling to Promote Tumorigenesis
por: Liang, Deguang, et al.
Publicado: (2014)

IKKα and IKKβ Each Function to Regulate NF-κB Activation in the TNF-Induced/Canonical Pathway
por: Adli, Mazhar, et al.
Publicado: (2010)

Structural and Biochemical Bases for the Inhibition of Autophagy and Apoptosis by Viral BCL-2 of Murine γ-Herpesvirus 68
por: Ku, Bonsu, et al.
Publicado: (2008)

NF-κB hijacking theranostic Pt(ll) complex in cancer therapy
por: Zhu, Yingzhong, et al.
Publicado: (2019)

Foreign RNA Induces the Degradation of Mitochondrial Antiviral Signaling Protein (MAVS): The Role of Intracellular Antiviral Factors
por: Xing, Fei, et al.
Publicado: (2012)

A novel TBK1/IKKϵ is involved in immune response and interacts with MyD88 and MAVS in the scallop Chlamys farreri
por: Liu, Wenjuan, et al.
Publicado: (2023)

Hijacking the Fusion Complex of Human Parainfluenza Virus as an Antiviral Strategy
por: Marcink, T. C., et al.
Publicado: (2020)

Cellular metabolism hijacked by viruses for immunoevasion: potential antiviral targets
por: Li, Jiaqi, et al.
Publicado: (2023)

Interplay of Murine Gammaherpesvirus 68 with NF-kappaB Signaling of the Host
por: Cieniewicz, Brandon, et al.
Publicado: (2016)

Kaposi's Sarcoma-Associated Herpesvirus K7 Induces Viral G Protein-Coupled Receptor Degradation and Reduces Its Tumorigenicity
por: Feng, Hao, et al.
Publicado: (2008)

TRAF5 Is a Downstream Target of MAVS in Antiviral Innate Immune Signaling
por: Tang, Eric D., et al.
Publicado: (2010)

Correction: Structural basis for the prion-like MAVS filaments in antiviral innate immunity
por: Xu, Hui, et al.
Publicado: (2015)

The oncogenic gamma herpesviruses Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) hijack retinoic acid-inducible gene I (RIG-I) facilitating both viral and tumour immune evasion
por: Nash, Alana, et al.
Publicado: (2022)

Correction: Oncogenic Herpesvirus KSHV Hijacks BMP-Smad1-Id Signaling to Promote Tumorigenesis
por: Liang, Deguang, et al.
Publicado: (2022)

The MAVS and MAV-Nots: PINK1 Clears Prion-like MAVS Aggregates to Extinguish Mitochondrial Inflammatory Signaling
por: Rai, Prashant, et al.
Publicado: (2021)

Influenza A virus NS1 protein represses antiviral immune response by hijacking NF-κB to mediate transcription of type III IFN
por: Lee, Meng-Chang, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_0ns8niaba54pbh57pdca5drn5t