A Non-Motor Microtubule Binding Site Is Essential for the High Processivity and Mitotic Function of Kinesin-8 Kif18A

BACKGROUND: Members of the kinesin-8 subfamily are plus end-directed molecular motors that accumulate at the plus-ends of kinetochore-microtubules (kt-MTs) where they regulate MT dynamics. Loss of vertebrate kinesin-8 function induces hyperstable MTs and elongated mitotic spindles accompanied by sev...

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Detalles Bibliográficos
Autores principales: Mayr, Monika I., Storch, Marko, Howard, Jonathon, Mayer, Thomas U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213134/
https://www.ncbi.nlm.nih.gov/pubmed/22102900
http://dx.doi.org/10.1371/journal.pone.0027471

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213134/
https://www.ncbi.nlm.nih.gov/pubmed/22102900
http://dx.doi.org/10.1371/journal.pone.0027471

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