Capture of MicroRNA–Bound mRNAs Identifies the Tumor Suppressor miR-34a as a Regulator of Growth Factor Signaling

A simple biochemical method to isolate mRNAs pulled down with a transfected, biotinylated microRNA was used to identify direct target genes of miR-34a, a tumor suppressor gene. The method reidentified most of the known miR-34a regulated genes expressed in K562 and HCT116 cancer cell lines. Transcrip...

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Detalles Bibliográficos
Autores principales: Lal, Ashish, Thomas, Marshall P., Altschuler, Gabriel, Navarro, Francisco, O'Day, Elizabeth, Li, Xiao Ling, Concepcion, Carla, Han, Yoon-Chi, Thiery, Jerome, Rajani, Danielle K., Deutsch, Aaron, Hofmann, Oliver, Ventura, Andrea, Hide, Winston, Lieberman, Judy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213160/
https://www.ncbi.nlm.nih.gov/pubmed/22102825
http://dx.doi.org/10.1371/journal.pgen.1002363

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