4-Phenyl-1-(prop-2-yn-1-yl)-1H-1,5-benzodiazepin-2(3H)-one

4-Phenyl-1H-1,5-benzodiazepin-2(3H)-one reacts in the pres­ence of a concentrated aqueous solution of sodium hydroxide and a quaternary ammonium salt (as catalyst) in benzene (phase transfer catalysis) with propargyl bromide, affording the title benzodiazepine derivative, C(18)H(14)N(2)O. In the mol...

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Autores principales: Loughzail, Mohamed, Fernandes, José A., Baouid, Abdesselam, Essaber, Mohamed, Cavaleiro, José A. S., Almeida Paz, Filipe A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2011
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213519/
https://www.ncbi.nlm.nih.gov/pubmed/22091098
http://dx.doi.org/10.1107/S1600536811027371
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author Loughzail, Mohamed
Fernandes, José A.
Baouid, Abdesselam
Essaber, Mohamed
Cavaleiro, José A. S.
Almeida Paz, Filipe A.
author_facet Loughzail, Mohamed
Fernandes, José A.
Baouid, Abdesselam
Essaber, Mohamed
Cavaleiro, José A. S.
Almeida Paz, Filipe A.
author_sort Loughzail, Mohamed
collection PubMed
description 4-Phenyl-1H-1,5-benzodiazepin-2(3H)-one reacts in the pres­ence of a concentrated aqueous solution of sodium hydroxide and a quaternary ammonium salt (as catalyst) in benzene (phase transfer catalysis) with propargyl bromide, affording the title benzodiazepine derivative, C(18)H(14)N(2)O. In the mol­ecule, the mean plane of the propargyl substituent is almost perpendicular with that of the amide group [dihedral angle = 87.81 (8)°]. In the crystal, the molecules are linked by C—H⋯O and C—H⋯N inter­actions.
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spelling pubmed-32135192011-11-16 4-Phenyl-1-(prop-2-yn-1-yl)-1H-1,5-benzodiazepin-2(3H)-one Loughzail, Mohamed Fernandes, José A. Baouid, Abdesselam Essaber, Mohamed Cavaleiro, José A. S. Almeida Paz, Filipe A. Acta Crystallogr Sect E Struct Rep Online Organic Papers 4-Phenyl-1H-1,5-benzodiazepin-2(3H)-one reacts in the pres­ence of a concentrated aqueous solution of sodium hydroxide and a quaternary ammonium salt (as catalyst) in benzene (phase transfer catalysis) with propargyl bromide, affording the title benzodiazepine derivative, C(18)H(14)N(2)O. In the mol­ecule, the mean plane of the propargyl substituent is almost perpendicular with that of the amide group [dihedral angle = 87.81 (8)°]. In the crystal, the molecules are linked by C—H⋯O and C—H⋯N inter­actions. International Union of Crystallography 2011-07-23 /pmc/articles/PMC3213519/ /pubmed/22091098 http://dx.doi.org/10.1107/S1600536811027371 Text en © Loughzail et al. 2011 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Loughzail, Mohamed
Fernandes, José A.
Baouid, Abdesselam
Essaber, Mohamed
Cavaleiro, José A. S.
Almeida Paz, Filipe A.
4-Phenyl-1-(prop-2-yn-1-yl)-1H-1,5-benzodiazepin-2(3H)-one
title 4-Phenyl-1-(prop-2-yn-1-yl)-1H-1,5-benzodiazepin-2(3H)-one
title_full 4-Phenyl-1-(prop-2-yn-1-yl)-1H-1,5-benzodiazepin-2(3H)-one
title_fullStr 4-Phenyl-1-(prop-2-yn-1-yl)-1H-1,5-benzodiazepin-2(3H)-one
title_full_unstemmed 4-Phenyl-1-(prop-2-yn-1-yl)-1H-1,5-benzodiazepin-2(3H)-one
title_short 4-Phenyl-1-(prop-2-yn-1-yl)-1H-1,5-benzodiazepin-2(3H)-one
title_sort 4-phenyl-1-(prop-2-yn-1-yl)-1h-1,5-benzodiazepin-2(3h)-one
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213519/
https://www.ncbi.nlm.nih.gov/pubmed/22091098
http://dx.doi.org/10.1107/S1600536811027371
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