DNA Replication Timing Is Maintained Genome-Wide in Primary Human Myoblasts Independent of D4Z4 Contraction in FSH Muscular Dystrophy

Facioscapulohumeral muscular dystrophy (FSHD) is linked to contraction of an array of tandem 3.3-kb repeats (D4Z4) at 4q35.2 from 11-100 copies to 1-10 copies. The extent to which D4Z4 contraction at 4q35.2 affects overall 4q35.2 chromatin organization remains unclear. Because DNA replication timing...

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Detalles Bibliográficos
Autores principales: Pope, Benjamin D., Tsumagari, Koji, Battaglia, Dana, Ryba, Tyrone, Hiratani, Ichiro, Ehrlich, Melanie, Gilbert, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214052/
https://www.ncbi.nlm.nih.gov/pubmed/22096571
http://dx.doi.org/10.1371/journal.pone.0027413

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