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Role of hydrocortisone in prevention of pain on propofol injection

BACKGROUND AND OBJECTIVES: Pain following intravenous injection of propofol continues to be an intriguing problem. None of the commonly used methods completely attenuate the pain. Inflammatory response to propofol contributes to the pain. Role of hydrocortisone in attenuating pain has not been evalu...

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Autores principales: Yadav, Monu, Durga, Padmaja, Gopinath, R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications Pvt Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214550/
https://www.ncbi.nlm.nih.gov/pubmed/22096278
http://dx.doi.org/10.4103/0970-9185.86582
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author Yadav, Monu
Durga, Padmaja
Gopinath, R
author_facet Yadav, Monu
Durga, Padmaja
Gopinath, R
author_sort Yadav, Monu
collection PubMed
description BACKGROUND AND OBJECTIVES: Pain following intravenous injection of propofol continues to be an intriguing problem. None of the commonly used methods completely attenuate the pain. Inflammatory response to propofol contributes to the pain. Role of hydrocortisone in attenuating pain has not been evaluated. This study was conducted to compare the efficacy of lignocaine and hydrocortisone in attenuation of pain following intravenous injection of propofol. MATERIALS AND METHODS: A prospective randomized double-blind, placebo-controlled study was conducted on 72 adult patients belonging to American Society of Anesthesiologists (ASA) physical status I or II, scheduled to undergo elective surgery. They were randomly assigned to four groups of 18 each. Group NS, group LG, group HC10, and group HC25. The groups received 2 ml normal saline, 2 ml 2% lignocaine, 10 mg/2 ml hydrocortisone, and 25 mg/2 ml hydrocortisone, respectively, as pretreatment. Propofol was injected 30 sec later. A blinded researcher assessed the patient's pain level using a four point verbal rating scale. RESULTS: The four groups were comparable in respect to patient's characteristics. There was no significant difference of hemodynamics changes during propofol induction between all the groups. There was no statistically significant difference in the incidence of pain between patients who received hydrocortisone and the placebo group. The incidence of pain was significantly less in group LG than other three groups. CONCLUSION: Use of intravenous low dose hydrocortisone pretreatment of the vein does not attenuate pain following propofol injection.
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spelling pubmed-32145502011-11-17 Role of hydrocortisone in prevention of pain on propofol injection Yadav, Monu Durga, Padmaja Gopinath, R J Anaesthesiol Clin Pharmacol Original Article BACKGROUND AND OBJECTIVES: Pain following intravenous injection of propofol continues to be an intriguing problem. None of the commonly used methods completely attenuate the pain. Inflammatory response to propofol contributes to the pain. Role of hydrocortisone in attenuating pain has not been evaluated. This study was conducted to compare the efficacy of lignocaine and hydrocortisone in attenuation of pain following intravenous injection of propofol. MATERIALS AND METHODS: A prospective randomized double-blind, placebo-controlled study was conducted on 72 adult patients belonging to American Society of Anesthesiologists (ASA) physical status I or II, scheduled to undergo elective surgery. They were randomly assigned to four groups of 18 each. Group NS, group LG, group HC10, and group HC25. The groups received 2 ml normal saline, 2 ml 2% lignocaine, 10 mg/2 ml hydrocortisone, and 25 mg/2 ml hydrocortisone, respectively, as pretreatment. Propofol was injected 30 sec later. A blinded researcher assessed the patient's pain level using a four point verbal rating scale. RESULTS: The four groups were comparable in respect to patient's characteristics. There was no significant difference of hemodynamics changes during propofol induction between all the groups. There was no statistically significant difference in the incidence of pain between patients who received hydrocortisone and the placebo group. The incidence of pain was significantly less in group LG than other three groups. CONCLUSION: Use of intravenous low dose hydrocortisone pretreatment of the vein does not attenuate pain following propofol injection. Medknow Publications Pvt Ltd 2011 /pmc/articles/PMC3214550/ /pubmed/22096278 http://dx.doi.org/10.4103/0970-9185.86582 Text en Copyright: © Journal of Anaesthesiology Clinical Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yadav, Monu
Durga, Padmaja
Gopinath, R
Role of hydrocortisone in prevention of pain on propofol injection
title Role of hydrocortisone in prevention of pain on propofol injection
title_full Role of hydrocortisone in prevention of pain on propofol injection
title_fullStr Role of hydrocortisone in prevention of pain on propofol injection
title_full_unstemmed Role of hydrocortisone in prevention of pain on propofol injection
title_short Role of hydrocortisone in prevention of pain on propofol injection
title_sort role of hydrocortisone in prevention of pain on propofol injection
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214550/
https://www.ncbi.nlm.nih.gov/pubmed/22096278
http://dx.doi.org/10.4103/0970-9185.86582
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