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Role of hydrocortisone in prevention of pain on propofol injection
BACKGROUND AND OBJECTIVES: Pain following intravenous injection of propofol continues to be an intriguing problem. None of the commonly used methods completely attenuate the pain. Inflammatory response to propofol contributes to the pain. Role of hydrocortisone in attenuating pain has not been evalu...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications Pvt Ltd
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214550/ https://www.ncbi.nlm.nih.gov/pubmed/22096278 http://dx.doi.org/10.4103/0970-9185.86582 |
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author | Yadav, Monu Durga, Padmaja Gopinath, R |
author_facet | Yadav, Monu Durga, Padmaja Gopinath, R |
author_sort | Yadav, Monu |
collection | PubMed |
description | BACKGROUND AND OBJECTIVES: Pain following intravenous injection of propofol continues to be an intriguing problem. None of the commonly used methods completely attenuate the pain. Inflammatory response to propofol contributes to the pain. Role of hydrocortisone in attenuating pain has not been evaluated. This study was conducted to compare the efficacy of lignocaine and hydrocortisone in attenuation of pain following intravenous injection of propofol. MATERIALS AND METHODS: A prospective randomized double-blind, placebo-controlled study was conducted on 72 adult patients belonging to American Society of Anesthesiologists (ASA) physical status I or II, scheduled to undergo elective surgery. They were randomly assigned to four groups of 18 each. Group NS, group LG, group HC10, and group HC25. The groups received 2 ml normal saline, 2 ml 2% lignocaine, 10 mg/2 ml hydrocortisone, and 25 mg/2 ml hydrocortisone, respectively, as pretreatment. Propofol was injected 30 sec later. A blinded researcher assessed the patient's pain level using a four point verbal rating scale. RESULTS: The four groups were comparable in respect to patient's characteristics. There was no significant difference of hemodynamics changes during propofol induction between all the groups. There was no statistically significant difference in the incidence of pain between patients who received hydrocortisone and the placebo group. The incidence of pain was significantly less in group LG than other three groups. CONCLUSION: Use of intravenous low dose hydrocortisone pretreatment of the vein does not attenuate pain following propofol injection. |
format | Online Article Text |
id | pubmed-3214550 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Medknow Publications Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-32145502011-11-17 Role of hydrocortisone in prevention of pain on propofol injection Yadav, Monu Durga, Padmaja Gopinath, R J Anaesthesiol Clin Pharmacol Original Article BACKGROUND AND OBJECTIVES: Pain following intravenous injection of propofol continues to be an intriguing problem. None of the commonly used methods completely attenuate the pain. Inflammatory response to propofol contributes to the pain. Role of hydrocortisone in attenuating pain has not been evaluated. This study was conducted to compare the efficacy of lignocaine and hydrocortisone in attenuation of pain following intravenous injection of propofol. MATERIALS AND METHODS: A prospective randomized double-blind, placebo-controlled study was conducted on 72 adult patients belonging to American Society of Anesthesiologists (ASA) physical status I or II, scheduled to undergo elective surgery. They were randomly assigned to four groups of 18 each. Group NS, group LG, group HC10, and group HC25. The groups received 2 ml normal saline, 2 ml 2% lignocaine, 10 mg/2 ml hydrocortisone, and 25 mg/2 ml hydrocortisone, respectively, as pretreatment. Propofol was injected 30 sec later. A blinded researcher assessed the patient's pain level using a four point verbal rating scale. RESULTS: The four groups were comparable in respect to patient's characteristics. There was no significant difference of hemodynamics changes during propofol induction between all the groups. There was no statistically significant difference in the incidence of pain between patients who received hydrocortisone and the placebo group. The incidence of pain was significantly less in group LG than other three groups. CONCLUSION: Use of intravenous low dose hydrocortisone pretreatment of the vein does not attenuate pain following propofol injection. Medknow Publications Pvt Ltd 2011 /pmc/articles/PMC3214550/ /pubmed/22096278 http://dx.doi.org/10.4103/0970-9185.86582 Text en Copyright: © Journal of Anaesthesiology Clinical Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Yadav, Monu Durga, Padmaja Gopinath, R Role of hydrocortisone in prevention of pain on propofol injection |
title | Role of hydrocortisone in prevention of pain on propofol injection |
title_full | Role of hydrocortisone in prevention of pain on propofol injection |
title_fullStr | Role of hydrocortisone in prevention of pain on propofol injection |
title_full_unstemmed | Role of hydrocortisone in prevention of pain on propofol injection |
title_short | Role of hydrocortisone in prevention of pain on propofol injection |
title_sort | role of hydrocortisone in prevention of pain on propofol injection |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214550/ https://www.ncbi.nlm.nih.gov/pubmed/22096278 http://dx.doi.org/10.4103/0970-9185.86582 |
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