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Subacute Neurological Deterioration with Selective Axonal Injury in Patients with Acute Ischemic Stroke following Reperfusion of Middle Cerebral Artery Occlusion

To date, the long-term effects of reperfusion on the salvaged brain tissues have not been addressed in the literature. We report 4 cases presenting subacute neurological deteriorations with selective axonal injury following reperfusion therapies for acute ischemic stroke. Our case series based on 4...

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Autores principales: Hwang, Yang-Ha, Kim, Yong-Won, Kim, Jongyeol, Kim, Yong-Sun, Park, Sung-Pa, Suh, Chung-Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214670/
https://www.ncbi.nlm.nih.gov/pubmed/22087099
http://dx.doi.org/10.1159/000331450
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author Hwang, Yang-Ha
Kim, Yong-Won
Kim, Jongyeol
Kim, Yong-Sun
Park, Sung-Pa
Suh, Chung-Kyu
author_facet Hwang, Yang-Ha
Kim, Yong-Won
Kim, Jongyeol
Kim, Yong-Sun
Park, Sung-Pa
Suh, Chung-Kyu
author_sort Hwang, Yang-Ha
collection PubMed
description To date, the long-term effects of reperfusion on the salvaged brain tissues have not been addressed in the literature. We report 4 cases presenting subacute neurological deteriorations with selective axonal injury following reperfusion therapies for acute ischemic stroke. Our case series based on 4 patients showed common features distinct from those of early reperfusion injury in that (1) the neurological symptoms developed after 1-2 months of reperfusion therapies, (2) these symptoms were accompanied by the subcortical white matter changes on brain MRI, and (3) these findings were mostly reversible with time. This suggests that axons in the reperfused brain may be vulnerable to further neurological injury.
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spelling pubmed-32146702011-11-15 Subacute Neurological Deterioration with Selective Axonal Injury in Patients with Acute Ischemic Stroke following Reperfusion of Middle Cerebral Artery Occlusion Hwang, Yang-Ha Kim, Yong-Won Kim, Jongyeol Kim, Yong-Sun Park, Sung-Pa Suh, Chung-Kyu Case Rep Neurol Published: September 2011 To date, the long-term effects of reperfusion on the salvaged brain tissues have not been addressed in the literature. We report 4 cases presenting subacute neurological deteriorations with selective axonal injury following reperfusion therapies for acute ischemic stroke. Our case series based on 4 patients showed common features distinct from those of early reperfusion injury in that (1) the neurological symptoms developed after 1-2 months of reperfusion therapies, (2) these symptoms were accompanied by the subcortical white matter changes on brain MRI, and (3) these findings were mostly reversible with time. This suggests that axons in the reperfused brain may be vulnerable to further neurological injury. S. Karger AG 2011-09-07 /pmc/articles/PMC3214670/ /pubmed/22087099 http://dx.doi.org/10.1159/000331450 Text en Copyright © 2011 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published: September 2011
Hwang, Yang-Ha
Kim, Yong-Won
Kim, Jongyeol
Kim, Yong-Sun
Park, Sung-Pa
Suh, Chung-Kyu
Subacute Neurological Deterioration with Selective Axonal Injury in Patients with Acute Ischemic Stroke following Reperfusion of Middle Cerebral Artery Occlusion
title Subacute Neurological Deterioration with Selective Axonal Injury in Patients with Acute Ischemic Stroke following Reperfusion of Middle Cerebral Artery Occlusion
title_full Subacute Neurological Deterioration with Selective Axonal Injury in Patients with Acute Ischemic Stroke following Reperfusion of Middle Cerebral Artery Occlusion
title_fullStr Subacute Neurological Deterioration with Selective Axonal Injury in Patients with Acute Ischemic Stroke following Reperfusion of Middle Cerebral Artery Occlusion
title_full_unstemmed Subacute Neurological Deterioration with Selective Axonal Injury in Patients with Acute Ischemic Stroke following Reperfusion of Middle Cerebral Artery Occlusion
title_short Subacute Neurological Deterioration with Selective Axonal Injury in Patients with Acute Ischemic Stroke following Reperfusion of Middle Cerebral Artery Occlusion
title_sort subacute neurological deterioration with selective axonal injury in patients with acute ischemic stroke following reperfusion of middle cerebral artery occlusion
topic Published: September 2011
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214670/
https://www.ncbi.nlm.nih.gov/pubmed/22087099
http://dx.doi.org/10.1159/000331450
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