Neurotoxic Effects of Tetrahydroisoquinolines and Underlying Mechanisms

Tetrahydropapaveroline (THP), a neurotoxic tetrahydroisoquinoline alkaloid formed by condensation between dopamine and dopaldehyde, has been speculated to cause Parkinson's disease and also to contribute to alcohol dependence. Having two catechol moieties, THP may readily undergo oxidation to f...

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Detalles Bibliográficos
Autores principales: Surh, Young-Joon, Kim, Hyun-Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Brain and Neural Science 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214777/
https://www.ncbi.nlm.nih.gov/pubmed/22110343
http://dx.doi.org/10.5607/en.2010.19.2.63
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author Surh, Young-Joon
Kim, Hyun-Jung
author_facet Surh, Young-Joon
Kim, Hyun-Jung
author_sort Surh, Young-Joon
collection PubMed
description Tetrahydropapaveroline (THP), a neurotoxic tetrahydroisoquinoline alkaloid formed by condensation between dopamine and dopaldehyde, has been speculated to cause Parkinson's disease and also to contribute to alcohol dependence. Having two catechol moieties, THP may readily undergo oxidation to form an o-quinone intermediate with concomitant production of reactive oxygen species, which can cause neuronal cell death and DNA damage. This review will deal with the current knowledge of neurotoxic effects of this endogenous alkaloid and underlying biochemical mechanisms.
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spelling pubmed-32147772011-11-22 Neurotoxic Effects of Tetrahydroisoquinolines and Underlying Mechanisms Surh, Young-Joon Kim, Hyun-Jung Exp Neurobiol Review Tetrahydropapaveroline (THP), a neurotoxic tetrahydroisoquinoline alkaloid formed by condensation between dopamine and dopaldehyde, has been speculated to cause Parkinson's disease and also to contribute to alcohol dependence. Having two catechol moieties, THP may readily undergo oxidation to form an o-quinone intermediate with concomitant production of reactive oxygen species, which can cause neuronal cell death and DNA damage. This review will deal with the current knowledge of neurotoxic effects of this endogenous alkaloid and underlying biochemical mechanisms. The Korean Society for Brain and Neural Science 2010-09 2010-09-30 /pmc/articles/PMC3214777/ /pubmed/22110343 http://dx.doi.org/10.5607/en.2010.19.2.63 Text en Copyright © Experimental Neurobiology 2010. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Surh, Young-Joon
Kim, Hyun-Jung
Neurotoxic Effects of Tetrahydroisoquinolines and Underlying Mechanisms
title Neurotoxic Effects of Tetrahydroisoquinolines and Underlying Mechanisms
title_full Neurotoxic Effects of Tetrahydroisoquinolines and Underlying Mechanisms
title_fullStr Neurotoxic Effects of Tetrahydroisoquinolines and Underlying Mechanisms
title_full_unstemmed Neurotoxic Effects of Tetrahydroisoquinolines and Underlying Mechanisms
title_short Neurotoxic Effects of Tetrahydroisoquinolines and Underlying Mechanisms
title_sort neurotoxic effects of tetrahydroisoquinolines and underlying mechanisms
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214777/
https://www.ncbi.nlm.nih.gov/pubmed/22110343
http://dx.doi.org/10.5607/en.2010.19.2.63
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