The Role of Axonopathy in Parkinson's Disease

New genetic and environmental studies of Parkinson's disease have revealed early problems in synaptic function and connectivity indicating that axonal impairment may be an important hallmark in this disorder. Since many studies suggest that axonal dysfunction precedes cell body loss, it is crit...

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Detalles Bibliográficos
Autor principal: O'Malley, Karen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Brain and Neural Science 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214783/
https://www.ncbi.nlm.nih.gov/pubmed/22110350
http://dx.doi.org/10.5607/en.2010.19.3.115
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author O'Malley, Karen L.
author_facet O'Malley, Karen L.
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description New genetic and environmental studies of Parkinson's disease have revealed early problems in synaptic function and connectivity indicating that axonal impairment may be an important hallmark in this disorder. Since many studies suggest that axonal dysfunction precedes cell body loss, it is critical to target axons with treatments aimed at preserving "connectivity" as well as to develop and verify "biomarkers" with which to assess disease progression and drug efficacy.
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spelling pubmed-32147832011-11-22 The Role of Axonopathy in Parkinson's Disease O'Malley, Karen L. Exp Neurobiol Review New genetic and environmental studies of Parkinson's disease have revealed early problems in synaptic function and connectivity indicating that axonal impairment may be an important hallmark in this disorder. Since many studies suggest that axonal dysfunction precedes cell body loss, it is critical to target axons with treatments aimed at preserving "connectivity" as well as to develop and verify "biomarkers" with which to assess disease progression and drug efficacy. The Korean Society for Brain and Neural Science 2010-12 2010-12-31 /pmc/articles/PMC3214783/ /pubmed/22110350 http://dx.doi.org/10.5607/en.2010.19.3.115 Text en Copyright © Experimental Neurobiology 2010. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
O'Malley, Karen L.
The Role of Axonopathy in Parkinson's Disease
title The Role of Axonopathy in Parkinson's Disease
title_full The Role of Axonopathy in Parkinson's Disease
title_fullStr The Role of Axonopathy in Parkinson's Disease
title_full_unstemmed The Role of Axonopathy in Parkinson's Disease
title_short The Role of Axonopathy in Parkinson's Disease
title_sort role of axonopathy in parkinson's disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214783/
https://www.ncbi.nlm.nih.gov/pubmed/22110350
http://dx.doi.org/10.5607/en.2010.19.3.115
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