Cargando…

Penile Growth in Response to Human Chorionic Gonadotropin (hCG) Treatment in Patients with Idiopathic Hypogonadotrophic Hypogonadism

Penile growth is under androgenic control. Human chorionic gonadotropin (hCG) has a stimulatory effect on testicular steroidogenesis and penile growth. The purpose of this study was to evaluate the effect of hCG treatment on the gonadal response and penile growth in male idiopathic hypogonadotrophic...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Sun-Ouck, Ryu, Kwang Ho, Hwang, In Sang, Jung, Seung Il, Oh, Kyung Jin, Park, Kwangsung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chonnam National University Medical School 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214853/
https://www.ncbi.nlm.nih.gov/pubmed/22111055
http://dx.doi.org/10.4068/cmj.2011.47.1.39
_version_ 1782216328621326336
author Kim, Sun-Ouck
Ryu, Kwang Ho
Hwang, In Sang
Jung, Seung Il
Oh, Kyung Jin
Park, Kwangsung
author_facet Kim, Sun-Ouck
Ryu, Kwang Ho
Hwang, In Sang
Jung, Seung Il
Oh, Kyung Jin
Park, Kwangsung
author_sort Kim, Sun-Ouck
collection PubMed
description Penile growth is under androgenic control. Human chorionic gonadotropin (hCG) has a stimulatory effect on testicular steroidogenesis and penile growth. The purpose of this study was to evaluate the effect of hCG treatment on the gonadal response and penile growth in male idiopathic hypogonadotrophic hypogonadism (IHH) presenting with micropenis. A total of 20 IHH patients who met the criteria for micropenis were included in this study. hCG (1,500-2,000 IU) was administrated intramuscularly, 3 times per week, for 8 weeks. Basic laboratory and hormonal indexes (including serum testosterone and LH levels), penis length (flaccid and stretched), and testicular volume were measured before and 24 weeks after hCG treatment. The patients' mean age was 18.9 years (range, 12 to 24 years). The mean serum testosterone level was significantly increased after hCG treatment (baseline, 2, 4, 12, and 24 weeks: 0.90±1.35 ng/ml, 1.77±1.31 ng/ml, 3.74±2.24 ng/ml, 5.49±1.70 ng/ml, and 5.58±1.75 ng/ml, respectively; p<0.05). Mean penile length also increased significantly 24 weeks after treatment (flaccid length: from 3.39±1.03 cm to 5.14±1.39 cm; stretched length: from 5.41±1.43 cm to 7.45±1.70 cm; p<0.001). Mean testicular volumes increased significantly as well (left: from 5.45 cc to 6.83 cc; right: from 5.53 cc to 7.03 cc). There were no remarkable adverse effects of the hCG treatment. The hCG treatment increased the serum testosterone level, penile length, and testicular volume in IHH patients. Our results suggest that hCG treatment has a beneficial effect on gonadal function and penile growth in patients with IHH presenting with micropenis.
format Online
Article
Text
id pubmed-3214853
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Chonnam National University Medical School
record_format MEDLINE/PubMed
spelling pubmed-32148532011-11-22 Penile Growth in Response to Human Chorionic Gonadotropin (hCG) Treatment in Patients with Idiopathic Hypogonadotrophic Hypogonadism Kim, Sun-Ouck Ryu, Kwang Ho Hwang, In Sang Jung, Seung Il Oh, Kyung Jin Park, Kwangsung Chonnam Med J Original Article Penile growth is under androgenic control. Human chorionic gonadotropin (hCG) has a stimulatory effect on testicular steroidogenesis and penile growth. The purpose of this study was to evaluate the effect of hCG treatment on the gonadal response and penile growth in male idiopathic hypogonadotrophic hypogonadism (IHH) presenting with micropenis. A total of 20 IHH patients who met the criteria for micropenis were included in this study. hCG (1,500-2,000 IU) was administrated intramuscularly, 3 times per week, for 8 weeks. Basic laboratory and hormonal indexes (including serum testosterone and LH levels), penis length (flaccid and stretched), and testicular volume were measured before and 24 weeks after hCG treatment. The patients' mean age was 18.9 years (range, 12 to 24 years). The mean serum testosterone level was significantly increased after hCG treatment (baseline, 2, 4, 12, and 24 weeks: 0.90±1.35 ng/ml, 1.77±1.31 ng/ml, 3.74±2.24 ng/ml, 5.49±1.70 ng/ml, and 5.58±1.75 ng/ml, respectively; p<0.05). Mean penile length also increased significantly 24 weeks after treatment (flaccid length: from 3.39±1.03 cm to 5.14±1.39 cm; stretched length: from 5.41±1.43 cm to 7.45±1.70 cm; p<0.001). Mean testicular volumes increased significantly as well (left: from 5.45 cc to 6.83 cc; right: from 5.53 cc to 7.03 cc). There were no remarkable adverse effects of the hCG treatment. The hCG treatment increased the serum testosterone level, penile length, and testicular volume in IHH patients. Our results suggest that hCG treatment has a beneficial effect on gonadal function and penile growth in patients with IHH presenting with micropenis. Chonnam National University Medical School 2011-04 2011-04-26 /pmc/articles/PMC3214853/ /pubmed/22111055 http://dx.doi.org/10.4068/cmj.2011.47.1.39 Text en © Chonnam Medical Journal, 2011 http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Sun-Ouck
Ryu, Kwang Ho
Hwang, In Sang
Jung, Seung Il
Oh, Kyung Jin
Park, Kwangsung
Penile Growth in Response to Human Chorionic Gonadotropin (hCG) Treatment in Patients with Idiopathic Hypogonadotrophic Hypogonadism
title Penile Growth in Response to Human Chorionic Gonadotropin (hCG) Treatment in Patients with Idiopathic Hypogonadotrophic Hypogonadism
title_full Penile Growth in Response to Human Chorionic Gonadotropin (hCG) Treatment in Patients with Idiopathic Hypogonadotrophic Hypogonadism
title_fullStr Penile Growth in Response to Human Chorionic Gonadotropin (hCG) Treatment in Patients with Idiopathic Hypogonadotrophic Hypogonadism
title_full_unstemmed Penile Growth in Response to Human Chorionic Gonadotropin (hCG) Treatment in Patients with Idiopathic Hypogonadotrophic Hypogonadism
title_short Penile Growth in Response to Human Chorionic Gonadotropin (hCG) Treatment in Patients with Idiopathic Hypogonadotrophic Hypogonadism
title_sort penile growth in response to human chorionic gonadotropin (hcg) treatment in patients with idiopathic hypogonadotrophic hypogonadism
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214853/
https://www.ncbi.nlm.nih.gov/pubmed/22111055
http://dx.doi.org/10.4068/cmj.2011.47.1.39
work_keys_str_mv AT kimsunouck penilegrowthinresponsetohumanchorionicgonadotropinhcgtreatmentinpatientswithidiopathichypogonadotrophichypogonadism
AT ryukwangho penilegrowthinresponsetohumanchorionicgonadotropinhcgtreatmentinpatientswithidiopathichypogonadotrophichypogonadism
AT hwanginsang penilegrowthinresponsetohumanchorionicgonadotropinhcgtreatmentinpatientswithidiopathichypogonadotrophichypogonadism
AT jungseungil penilegrowthinresponsetohumanchorionicgonadotropinhcgtreatmentinpatientswithidiopathichypogonadotrophichypogonadism
AT ohkyungjin penilegrowthinresponsetohumanchorionicgonadotropinhcgtreatmentinpatientswithidiopathichypogonadotrophichypogonadism
AT parkkwangsung penilegrowthinresponsetohumanchorionicgonadotropinhcgtreatmentinpatientswithidiopathichypogonadotrophichypogonadism