Cargando…

Extracellular NM23 Signaling in Breast Cancer: Incommodus Verum

The notion that breast cancers can survive in an individual patient in a dormant state only to grow as metastatic disease in the future, is in our view incontrovertibly established. Convincing too is the evidence that surgery to remove the primary tumor often terminates dormancy resulting in acceler...

Descripción completa

Detalles Bibliográficos
Autores principales: Buxton, Iain L.O., Yokdang, Nucharee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214996/
https://www.ncbi.nlm.nih.gov/pubmed/22091350
http://dx.doi.org/10.3390/cancers3032844
_version_ 1782216341557608448
author Buxton, Iain L.O.
Yokdang, Nucharee
author_facet Buxton, Iain L.O.
Yokdang, Nucharee
author_sort Buxton, Iain L.O.
collection PubMed
description The notion that breast cancers can survive in an individual patient in a dormant state only to grow as metastatic disease in the future, is in our view incontrovertibly established. Convincing too is the evidence that surgery to remove the primary tumor often terminates dormancy resulting in accelerated relapses. Accepting that many deaths due to breast cancer might be averted were we to understand the cellular mechanisms underlying escape from dormancy, we have examined the extracellular signals produced by breast cancers derived from women with metastatic breast disease. In this perspective, we explore the role of extracellular nucleotide signaling that we have proposed constitutes a pathological axis from the transformed tumor cell to the endothelium in the service of intravasation, dissemination, extravasation and angiogenesis. A role for the dinucleotide kinase NM23/NDPK (nucleoside diphosphate kinase) secreted by breast tumor cells in the generation of signals that stimulate vascular leakiness, anti-thrombosis, endothelial migration and growth, constitutes a mechanistic basis for escape from latency and offers putative therapeutic targets for breast cancer management not previously appreciated.
format Online
Article
Text
id pubmed-3214996
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Molecular Diversity Preservation International (MDPI)
record_format MEDLINE/PubMed
spelling pubmed-32149962011-11-14 Extracellular NM23 Signaling in Breast Cancer: Incommodus Verum Buxton, Iain L.O. Yokdang, Nucharee Cancers (Basel) Review The notion that breast cancers can survive in an individual patient in a dormant state only to grow as metastatic disease in the future, is in our view incontrovertibly established. Convincing too is the evidence that surgery to remove the primary tumor often terminates dormancy resulting in accelerated relapses. Accepting that many deaths due to breast cancer might be averted were we to understand the cellular mechanisms underlying escape from dormancy, we have examined the extracellular signals produced by breast cancers derived from women with metastatic breast disease. In this perspective, we explore the role of extracellular nucleotide signaling that we have proposed constitutes a pathological axis from the transformed tumor cell to the endothelium in the service of intravasation, dissemination, extravasation and angiogenesis. A role for the dinucleotide kinase NM23/NDPK (nucleoside diphosphate kinase) secreted by breast tumor cells in the generation of signals that stimulate vascular leakiness, anti-thrombosis, endothelial migration and growth, constitutes a mechanistic basis for escape from latency and offers putative therapeutic targets for breast cancer management not previously appreciated. Molecular Diversity Preservation International (MDPI) 2011-07-06 /pmc/articles/PMC3214996/ /pubmed/22091350 http://dx.doi.org/10.3390/cancers3032844 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Buxton, Iain L.O.
Yokdang, Nucharee
Extracellular NM23 Signaling in Breast Cancer: Incommodus Verum
title Extracellular NM23 Signaling in Breast Cancer: Incommodus Verum
title_full Extracellular NM23 Signaling in Breast Cancer: Incommodus Verum
title_fullStr Extracellular NM23 Signaling in Breast Cancer: Incommodus Verum
title_full_unstemmed Extracellular NM23 Signaling in Breast Cancer: Incommodus Verum
title_short Extracellular NM23 Signaling in Breast Cancer: Incommodus Verum
title_sort extracellular nm23 signaling in breast cancer: incommodus verum
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214996/
https://www.ncbi.nlm.nih.gov/pubmed/22091350
http://dx.doi.org/10.3390/cancers3032844
work_keys_str_mv AT buxtoniainlo extracellularnm23signalinginbreastcancerincommodusverum
AT yokdangnucharee extracellularnm23signalinginbreastcancerincommodusverum