Nanostructured Pt(NH(3))(4)Cl(2)/SiO(2) for nanomedicine: catalytic degradation of DNA in cancer cells

In vivo suppression of glioblastoma multiforme (GBM) in Wistar rats using silica-shelled biocatalytic Pt(NH(3))(4)Cl(2) nanoparticles is reported. These nanoparticles were synthesized by a sol-gel technique and characterized by SEM and HRTEM imaging. We confirmed morphological uniformity (30 nm) and...

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Detalles Bibliográficos
Autores principales: López, Tessy, Islas, Emma Ortíz, Alvarez Lemus, Mayra A., González, Richard Donald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: CoAction Publishing 2011
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215199/
https://www.ncbi.nlm.nih.gov/pubmed/22110876
http://dx.doi.org/10.3402/nano.v2i0.5461
Descripción
Sumario:In vivo suppression of glioblastoma multiforme (GBM) in Wistar rats using silica-shelled biocatalytic Pt(NH(3))(4)Cl(2) nanoparticles is reported. These nanoparticles were synthesized by a sol-gel technique and characterized by SEM and HRTEM imaging. We confirmed morphological uniformity (30 nm) and surface acidity of the nanoparticles, respectively, by TEM imaging and FTIR spectral analysis. Interestingly, treatment of Wistar rats intraperitoneally inoculated with C(6) cells using the biocatalysts resulted in considerable tumor shrinkage. Efficiency of the biocatalyst to shrink a tumor is superior to that by the commercial cytotoxic agent cisplatin. The tumor suppression property of Pt(NH(3))(4)Cl(2) nanoparticles is attributed to catalytic damage of DNA in C(6) cells.

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