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Research advances on flotillins
The proteins of flotillin-1 and flotillin-2 were originally discovered in axon regeneration of goldfish retinal ganglion cells. They are generally used as marker proteins of lipid rafts and considered to be scaffolding proteins of lipid microdomains. Although they are ubiquitously expressed and well...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215287/ https://www.ncbi.nlm.nih.gov/pubmed/22023811 http://dx.doi.org/10.1186/1743-422X-8-479 |
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author | Zhao, Feng Zhang, Jie Liu, Yong-Sheng Li, Li He, Ya-Li |
author_facet | Zhao, Feng Zhang, Jie Liu, Yong-Sheng Li, Li He, Ya-Li |
author_sort | Zhao, Feng |
collection | PubMed |
description | The proteins of flotillin-1 and flotillin-2 were originally discovered in axon regeneration of goldfish retinal ganglion cells. They are generally used as marker proteins of lipid rafts and considered to be scaffolding proteins of lipid microdomains. Although they are ubiquitously expressed and well-conserved from fly to man, their exact functions remain controversial. In this review, we summarize the structure of flotillins and some functions of them, such as regulating axon regeneration, endocytosis, T cell activation, insulin signaling, membrane protein recruitment, roles in the progression of some diseases and so on. |
format | Online Article Text |
id | pubmed-3215287 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-32152872011-11-15 Research advances on flotillins Zhao, Feng Zhang, Jie Liu, Yong-Sheng Li, Li He, Ya-Li Virol J Review The proteins of flotillin-1 and flotillin-2 were originally discovered in axon regeneration of goldfish retinal ganglion cells. They are generally used as marker proteins of lipid rafts and considered to be scaffolding proteins of lipid microdomains. Although they are ubiquitously expressed and well-conserved from fly to man, their exact functions remain controversial. In this review, we summarize the structure of flotillins and some functions of them, such as regulating axon regeneration, endocytosis, T cell activation, insulin signaling, membrane protein recruitment, roles in the progression of some diseases and so on. BioMed Central 2011-10-25 /pmc/articles/PMC3215287/ /pubmed/22023811 http://dx.doi.org/10.1186/1743-422X-8-479 Text en Copyright ©2011 Zhao et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Zhao, Feng Zhang, Jie Liu, Yong-Sheng Li, Li He, Ya-Li Research advances on flotillins |
title | Research advances on flotillins |
title_full | Research advances on flotillins |
title_fullStr | Research advances on flotillins |
title_full_unstemmed | Research advances on flotillins |
title_short | Research advances on flotillins |
title_sort | research advances on flotillins |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215287/ https://www.ncbi.nlm.nih.gov/pubmed/22023811 http://dx.doi.org/10.1186/1743-422X-8-479 |
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