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The clinical impact of late gadolinium enhancement in Takotsubo cardiomyopathy: serial analysis of cardiovascular magnetic resonance images

BACKGROUND: Our study aimed to investigate both the clinical implications of late gadolinium enhancement (LGE) by cardiovascular magnetic resonance (CMR) and the relation of LGE to clinical findings in patients with Takotsubo cardiomyopathy (TTC). METHODS: We evaluated 20 consecutive patients (2 men...

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Autores principales: Naruse, Yoshihisa, Sato, Akira, Kasahara, Kazuyuki, Makino, Kiwa, Sano, Makoto, Takeuchi, Yasuyo, Nagasaka, Shiro, Wakabayashi, Yasushi, Katoh, Hideki, Satoh, Hiroshi, Hayashi, Hideharu, Aonuma, Kazutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215669/
https://www.ncbi.nlm.nih.gov/pubmed/22035445
http://dx.doi.org/10.1186/1532-429X-13-67
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author Naruse, Yoshihisa
Sato, Akira
Kasahara, Kazuyuki
Makino, Kiwa
Sano, Makoto
Takeuchi, Yasuyo
Nagasaka, Shiro
Wakabayashi, Yasushi
Katoh, Hideki
Satoh, Hiroshi
Hayashi, Hideharu
Aonuma, Kazutaka
author_facet Naruse, Yoshihisa
Sato, Akira
Kasahara, Kazuyuki
Makino, Kiwa
Sano, Makoto
Takeuchi, Yasuyo
Nagasaka, Shiro
Wakabayashi, Yasushi
Katoh, Hideki
Satoh, Hiroshi
Hayashi, Hideharu
Aonuma, Kazutaka
author_sort Naruse, Yoshihisa
collection PubMed
description BACKGROUND: Our study aimed to investigate both the clinical implications of late gadolinium enhancement (LGE) by cardiovascular magnetic resonance (CMR) and the relation of LGE to clinical findings in patients with Takotsubo cardiomyopathy (TTC). METHODS: We evaluated 20 consecutive patients (2 men, 18 women; median age, 77 years; interquartile range [IQR] 67-82 years) who were admitted to our hospital with the diagnosis of TTC. CMR was performed within 1 week after admission, and follow-up studies were conducted 1.5 and 6 months later. RESULTS: In 8 patients, CMR imaging during the sub-acute phase revealed LGE in the area matched with wall motion impairment. Cardiogenic shock was more frequently observed in patients with LGE than in those without LGE (38% vs 0%, p = 0.049). The patients with LGE needed a longer duration for ECG normalization and recovery of wall motion than did those without LGE (median 205 days, IQR [152-363] vs 68 days, [43-145], p = 0.005; 15 days, [10-185] vs 7 days, [4-13], p = 0.030, respectively). In 5 of these 8 patients, LGE disappeared within 45-180 days (170, IQR [56-180]) of onset. The patients with LGE remaining in the chronic phase had higher peak creatine kinase levels than did those without LGE (median 307 IU/L, IQR [264-460] vs 202 IU/L, [120-218], p = 0.017). CONCLUSION: LGE by CMR in the sub-acute phase may be associated with the severity and prolonged recovery to normal of clinical findings in TTC.
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spelling pubmed-32156692011-11-15 The clinical impact of late gadolinium enhancement in Takotsubo cardiomyopathy: serial analysis of cardiovascular magnetic resonance images Naruse, Yoshihisa Sato, Akira Kasahara, Kazuyuki Makino, Kiwa Sano, Makoto Takeuchi, Yasuyo Nagasaka, Shiro Wakabayashi, Yasushi Katoh, Hideki Satoh, Hiroshi Hayashi, Hideharu Aonuma, Kazutaka J Cardiovasc Magn Reson Research BACKGROUND: Our study aimed to investigate both the clinical implications of late gadolinium enhancement (LGE) by cardiovascular magnetic resonance (CMR) and the relation of LGE to clinical findings in patients with Takotsubo cardiomyopathy (TTC). METHODS: We evaluated 20 consecutive patients (2 men, 18 women; median age, 77 years; interquartile range [IQR] 67-82 years) who were admitted to our hospital with the diagnosis of TTC. CMR was performed within 1 week after admission, and follow-up studies were conducted 1.5 and 6 months later. RESULTS: In 8 patients, CMR imaging during the sub-acute phase revealed LGE in the area matched with wall motion impairment. Cardiogenic shock was more frequently observed in patients with LGE than in those without LGE (38% vs 0%, p = 0.049). The patients with LGE needed a longer duration for ECG normalization and recovery of wall motion than did those without LGE (median 205 days, IQR [152-363] vs 68 days, [43-145], p = 0.005; 15 days, [10-185] vs 7 days, [4-13], p = 0.030, respectively). In 5 of these 8 patients, LGE disappeared within 45-180 days (170, IQR [56-180]) of onset. The patients with LGE remaining in the chronic phase had higher peak creatine kinase levels than did those without LGE (median 307 IU/L, IQR [264-460] vs 202 IU/L, [120-218], p = 0.017). CONCLUSION: LGE by CMR in the sub-acute phase may be associated with the severity and prolonged recovery to normal of clinical findings in TTC. BioMed Central 2011-10-29 /pmc/articles/PMC3215669/ /pubmed/22035445 http://dx.doi.org/10.1186/1532-429X-13-67 Text en Copyright ©2011 Naruse et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Naruse, Yoshihisa
Sato, Akira
Kasahara, Kazuyuki
Makino, Kiwa
Sano, Makoto
Takeuchi, Yasuyo
Nagasaka, Shiro
Wakabayashi, Yasushi
Katoh, Hideki
Satoh, Hiroshi
Hayashi, Hideharu
Aonuma, Kazutaka
The clinical impact of late gadolinium enhancement in Takotsubo cardiomyopathy: serial analysis of cardiovascular magnetic resonance images
title The clinical impact of late gadolinium enhancement in Takotsubo cardiomyopathy: serial analysis of cardiovascular magnetic resonance images
title_full The clinical impact of late gadolinium enhancement in Takotsubo cardiomyopathy: serial analysis of cardiovascular magnetic resonance images
title_fullStr The clinical impact of late gadolinium enhancement in Takotsubo cardiomyopathy: serial analysis of cardiovascular magnetic resonance images
title_full_unstemmed The clinical impact of late gadolinium enhancement in Takotsubo cardiomyopathy: serial analysis of cardiovascular magnetic resonance images
title_short The clinical impact of late gadolinium enhancement in Takotsubo cardiomyopathy: serial analysis of cardiovascular magnetic resonance images
title_sort clinical impact of late gadolinium enhancement in takotsubo cardiomyopathy: serial analysis of cardiovascular magnetic resonance images
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215669/
https://www.ncbi.nlm.nih.gov/pubmed/22035445
http://dx.doi.org/10.1186/1532-429X-13-67
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