An MSI Tumor Specific Frameshift Mutation in a Coding Microsatellite of MSH3 Encodes for HLA-A0201-Restricted CD8(+) Cytotoxic T Cell Epitopes

BACKGROUND: Microsatellite instability (MSI) resulting from inactivation of the DNA mismatch repair system (MMR) characterizes a highly immunological subtype of colorectal carcinomas. Those tumors express multiple frameshift-mutated proteins which present a unique pool of tumor-specific antigens. Th...

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Detalles Bibliográficos
Autores principales: Garbe, Yvette, Maletzki, Claudia, Linnebacher, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215711/
https://www.ncbi.nlm.nih.gov/pubmed/22110587
http://dx.doi.org/10.1371/journal.pone.0026517

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215711/
https://www.ncbi.nlm.nih.gov/pubmed/22110587
http://dx.doi.org/10.1371/journal.pone.0026517

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