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An MSI Tumor Specific Frameshift Mutation in a Coding Microsatellite of MSH3 Encodes for HLA-A0201-Restricted CD8(+) Cytotoxic T Cell Epitopes

BACKGROUND: Microsatellite instability (MSI) resulting from inactivation of the DNA mismatch repair system (MMR) characterizes a highly immunological subtype of colorectal carcinomas. Those tumors express multiple frameshift-mutated proteins which present a unique pool of tumor-specific antigens. Th...

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Detalles Bibliográficos
Autores principales:	Garbe, Yvette, Maletzki, Claudia, Linnebacher, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215711/ https://www.ncbi.nlm.nih.gov/pubmed/22110587 http://dx.doi.org/10.1371/journal.pone.0026517

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