Cargando…

A TNF Receptor 2 Selective Agonist Rescues Human Neurons from Oxidative Stress-Induced Cell Death

Tumor necrosis factor (TNF) plays a dual role in neurodegenerative diseases. Whereas TNF receptor (TNFR) 1 is predominantly associated with neurodegeneration, TNFR2 is involved in tissue regeneration and neuroprotection. Accordingly, the availability of TNFR2-selective agonists could allow the devel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fischer, Roman, Maier, Olaf, Siegemund, Martin, Wajant, Harald, Scheurich, Peter, Pfizenmaier, Klaus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215731/ https://www.ncbi.nlm.nih.gov/pubmed/22110694 http://dx.doi.org/10.1371/journal.pone.0027621

Ejemplares similares

Selective Targeting of TNF Receptors as a Novel Therapeutic Approach
por: Fischer, Roman, et al.
Publicado: (2020)

Selective Blocking of TNF Receptor 1 Attenuates Peritoneal Dialysis Fluid Induced Inflammation of the Peritoneum in Mice
por: Kälble, Florian, et al.
Publicado: (2016)

Antagonistic TNF Receptor One-Specific Antibody (ATROSAB): Receptor Binding and In Vitro Bioactivity
por: Richter, Fabian, et al.
Publicado: (2013)

Membrane Tumor Necrosis Factor (TNF) Induced Cooperative Signaling of TNFR60 and TNFR80 Favors Induction of Cell Death Rather Than Virus Production in HIV-infected T Cells
por: Lazdins, Janis K., et al.
Publicado: (1997)

Interrelation of Oxidative Stress and Inflammation in Neurodegenerative Disease: Role of TNF
por: Fischer, Roman, et al.
Publicado: (2015)

Antitumor Activity of a Mesenchymal Stem Cell Line Stably Secreting a Tumor-Targeted TNF-Related Apoptosis-Inducing Ligand Fusion Protein
por: Marini, Irene, et al.
Publicado: (2017)

Membrane lymphotoxin-α(2)β is a novel tumor necrosis factor (TNF) receptor 2 (TNFR2) agonist
por: Kucka, Kirstin, et al.
Publicado: (2021)

Molecular Mode of Action of TRAIL Receptor Agonists—Common Principles and Their Translational Exploitation
por: Wajant, Harald
Publicado: (2019)

TNF-Receptor-1 inhibition reduces liver steatosis, hepatocellular injury and fibrosis in NAFLD mice
por: Wandrer, Franziska, et al.
Publicado: (2020)

Heterogeneity reduces sensitivity of cell death for TNF-Stimuli
por: Schliemann, Monica, et al.
Publicado: (2011)

TNF Receptor Associated Factor 2 (TRAF2) Signaling in Cancer
por: Siegmund, Daniela, et al.
Publicado: (2022)

A TNF receptor 2 agonist ameliorates neuropathology and improves cognition in an Alzheimer’s disease mouse model
por: Ortí-Casañ, Natalia, et al.
Publicado: (2022)

Principles of antibody-mediated TNF receptor activation
por: Wajant, H
Publicado: (2015)

Editorial: TNFRSF agonists: mode of action and therapeutic opportunities
por: Obermajer, Nataša, et al.
Publicado: (2023)

E3-14.7K Is Recruited to TNF-Receptor 1 and Blocks TNF Cytolysis Independent from Interaction with Optineurin
por: Klingseisen, Laura, et al.
Publicado: (2012)

The extracellular domains of FasL and Fas are sufficient for the formation of supramolecular FasL-Fas clusters of high stability
por: Henkler, Frank, et al.
Publicado: (2005)

TNF Receptor-Associated Factor 1 is a Major Target of Soluble TWEAK
por: Carmona Arana, José Antonio, et al.
Publicado: (2014)

Redundant and receptor-specific activities of TRADD, RIPK1 and FADD in death receptor signaling
por: Füllsack, Simone, et al.
Publicado: (2019)

Neuroprotection: Rescue from Neuronal Death in the Brain
por: Lee, Bae Hwan
Publicado: (2021)

TNFR1 and TNFR2 in the Control of the Life and Death Balance of Macrophages
por: Wajant, Harald, et al.
Publicado: (2019)

Continuous infusion of an agonist of the tumor necrosis factor receptor 2 in the spinal cord improves recovery after traumatic contusive injury
por: Gerald, Marcus J., et al.
Publicado: (2019)

TRAF2 Controls Death Receptor-Induced Caspase-8 Processing and Facilitates Proinflammatory Signaling
por: Kreckel, Jennifer, et al.
Publicado: (2019)

An Antioxidant Phytotherapy to Rescue Neuronal Oxidative Stress
por: Lin, Zhihong, et al.
Publicado: (2011)

TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity
por: Yu, Xiaojie, et al.
Publicado: (2021)

Neuroprotection: Rescue from Neuronal Death in the Brain 2.0
por: Lee, Bae Hwan
Publicado: (2023)

Selection of a Full Agonist Combinatorial Antibody that Rescues Leptin Deficiency In Vivo
por: Tao, Pingdong, et al.
Publicado: (2020)

The NEDD8-activating enzyme inhibitor MLN4924 sensitizes a TNFR1(+) subgroup of multiple myeloma cells for TNF-induced cell death
por: El-Mesery, Mohamed, et al.
Publicado: (2019)

Receptor Oligomerization and Its Relevance for Signaling by Receptors of the Tumor Necrosis Factor Receptor Superfamily
por: Kucka, Kirstin, et al.
Publicado: (2021)

TNFRSF receptor-specific antibody fusion proteins with targeting controlled FcγR-independent agonistic activity
por: Medler, Juliane, et al.
Publicado: (2019)

IgG-single-chain TRAIL fusion proteins for tumour therapy
por: Siegemund, Martin, et al.
Publicado: (2018)

Liver-X-receptor agonists rescue axonal degeneration in SPG11-deficient neurons via regulating cholesterol trafficking
por: Chai, Eric, et al.
Publicado: (2023)

Cabergoline, Dopamine D2 Receptor Agonist, Prevents Neuronal Cell Death under Oxidative Stress via Reducing Excitotoxicity
por: Odaka, Haruki, et al.
Publicado: (2014)

The IKK Inhibitor Bay 11-7082 Induces Cell Death Independent from Inhibition of Activation of NFκB Transcription Factors
por: Rauert-Wunderlich, Hilka, et al.
Publicado: (2013)

Effects of TNFα receptor TNF-Rp55- or TNF-Rp75- deficiency on corneal neovascularization and lymphangiogenesis in the mouse
por: Maier, Anna-Karina B., et al.
Publicado: (2021)

Antibody-Mediated Inhibition of TNFR1 Attenuates Disease in a Mouse Model of Multiple Sclerosis
por: Williams, Sarah K., et al.
Publicado: (2014)

Cannabinoid receptor agonist protects cultured dopaminergic neurons from the death by the proteasomal dysfunction
por: Jeon, Posung, et al.
Publicado: (2011)

The Transmembrane Domains of TNF-Related Apoptosis-Inducing Ligand (TRAIL) Receptors 1 and 2 Co-Regulate Apoptotic Signaling Capacity
por: Neumann, Simon, et al.
Publicado: (2012)

Activation of TNF Receptor 2 Improves Synaptic Plasticity and Enhances Amyloid-β Clearance in an Alzheimer’s Disease Mouse Model with Humanized TNF Receptor 2
por: Ortí-Casañ, Natalia, et al.
Publicado: (2023)

Sequential treatment with a TNFR2 agonist and a TNFR1 antagonist improves outcomes in a humanized mouse model for MS
por: Pegoretti, Valentina, et al.
Publicado: (2023)

PGC-1α Agonist Rescues Doxorubicin-Induced Cardiomyopathy by Mitigating the Oxidative Stress and Necroptosis
por: Shipra, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_cstd9abul2ktagulpok4ude8k0