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The HIV-1 Vpu Viroporin Inhibitor BIT225 Does Not Affect Vpu-Mediated Tetherin Antagonism

Among its many roles, the HIV-1 accessory protein Vpu performs a viroporin function and also antagonizes the host cell restriction factor tetherin through its transmembrane domain. BIT225 is a small molecule inhibitor that specifically targets the Vpu viroporin function, which, in macrophages, resul...

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Detalles Bibliográficos
Autores principales:	Kuhl, Björn D., Cheng, Vicky, Donahue, Daniel A., Sloan, Richard D., Liang, Chen, Wilkinson, John, Wainberg, Mark A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215742/ https://www.ncbi.nlm.nih.gov/pubmed/22110710 http://dx.doi.org/10.1371/journal.pone.0027660

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