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The Association of APOE Genotype with Cognitive Function in Persons Aged 35 Years or Older

APOE genotype is associated with the risk of Alzheimer's disease. In the present study, we investigated whether APOE genotype was associated with cognitive function in predominantly middle-aged persons. In a population-based cohort of 4,135 persons aged 35 to 82 years (mean age (SD), 55 (12) ye...

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Autores principales: Izaks, Gerbrand J., Gansevoort, Ron T., van der Knaap, Aafke M., Navis, Gerjan, Dullaart, Robin P. F., Slaets, Joris P. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215744/
https://www.ncbi.nlm.nih.gov/pubmed/22110642
http://dx.doi.org/10.1371/journal.pone.0027415
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author Izaks, Gerbrand J.
Gansevoort, Ron T.
van der Knaap, Aafke M.
Navis, Gerjan
Dullaart, Robin P. F.
Slaets, Joris P. J.
author_facet Izaks, Gerbrand J.
Gansevoort, Ron T.
van der Knaap, Aafke M.
Navis, Gerjan
Dullaart, Robin P. F.
Slaets, Joris P. J.
author_sort Izaks, Gerbrand J.
collection PubMed
description APOE genotype is associated with the risk of Alzheimer's disease. In the present study, we investigated whether APOE genotype was associated with cognitive function in predominantly middle-aged persons. In a population-based cohort of 4,135 persons aged 35 to 82 years (mean age (SD), 55 (12) years), cognitive function was measured with the Ruff Figural Fluency Test (RFFT; worst score, 0 points; best score, 175 points). APOE genotype (rs429358 and rs7412) was determined by polymerase chain reaction. The mean RFFT score (SD) of the total cohort was 69 (26) points. Unadjusted, the mean RFFT score in homozygous APOE ε4 carriers was 4.66 points lower than in noncarriers (95% confidence interval, -9.84 to 0.51; p = 0.08). After adjustment for age and other risk factors, the mean RFFT score in homozygous APOE ε4 carriers was 5.24 points lower than in noncarriers (95% confidence interval, -9.41 to -1.07; p = 0.01). The difference in RFFT score was not dependent on age. There was no difference in RFFT score between heterozygous APOE ε4 carriers and noncarriers. The results indicated that homozygous APOE ε4 carriers aged 35 years or older had worse cognitive function than heterozygous carriers and noncarriers.
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spelling pubmed-32157442011-11-21 The Association of APOE Genotype with Cognitive Function in Persons Aged 35 Years or Older Izaks, Gerbrand J. Gansevoort, Ron T. van der Knaap, Aafke M. Navis, Gerjan Dullaart, Robin P. F. Slaets, Joris P. J. PLoS One Research Article APOE genotype is associated with the risk of Alzheimer's disease. In the present study, we investigated whether APOE genotype was associated with cognitive function in predominantly middle-aged persons. In a population-based cohort of 4,135 persons aged 35 to 82 years (mean age (SD), 55 (12) years), cognitive function was measured with the Ruff Figural Fluency Test (RFFT; worst score, 0 points; best score, 175 points). APOE genotype (rs429358 and rs7412) was determined by polymerase chain reaction. The mean RFFT score (SD) of the total cohort was 69 (26) points. Unadjusted, the mean RFFT score in homozygous APOE ε4 carriers was 4.66 points lower than in noncarriers (95% confidence interval, -9.84 to 0.51; p = 0.08). After adjustment for age and other risk factors, the mean RFFT score in homozygous APOE ε4 carriers was 5.24 points lower than in noncarriers (95% confidence interval, -9.41 to -1.07; p = 0.01). The difference in RFFT score was not dependent on age. There was no difference in RFFT score between heterozygous APOE ε4 carriers and noncarriers. The results indicated that homozygous APOE ε4 carriers aged 35 years or older had worse cognitive function than heterozygous carriers and noncarriers. Public Library of Science 2011-11-14 /pmc/articles/PMC3215744/ /pubmed/22110642 http://dx.doi.org/10.1371/journal.pone.0027415 Text en Izaks et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Izaks, Gerbrand J.
Gansevoort, Ron T.
van der Knaap, Aafke M.
Navis, Gerjan
Dullaart, Robin P. F.
Slaets, Joris P. J.
The Association of APOE Genotype with Cognitive Function in Persons Aged 35 Years or Older
title The Association of APOE Genotype with Cognitive Function in Persons Aged 35 Years or Older
title_full The Association of APOE Genotype with Cognitive Function in Persons Aged 35 Years or Older
title_fullStr The Association of APOE Genotype with Cognitive Function in Persons Aged 35 Years or Older
title_full_unstemmed The Association of APOE Genotype with Cognitive Function in Persons Aged 35 Years or Older
title_short The Association of APOE Genotype with Cognitive Function in Persons Aged 35 Years or Older
title_sort association of apoe genotype with cognitive function in persons aged 35 years or older
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215744/
https://www.ncbi.nlm.nih.gov/pubmed/22110642
http://dx.doi.org/10.1371/journal.pone.0027415
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