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The Association of APOE Genotype with Cognitive Function in Persons Aged 35 Years or Older
APOE genotype is associated with the risk of Alzheimer's disease. In the present study, we investigated whether APOE genotype was associated with cognitive function in predominantly middle-aged persons. In a population-based cohort of 4,135 persons aged 35 to 82 years (mean age (SD), 55 (12) ye...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215744/ https://www.ncbi.nlm.nih.gov/pubmed/22110642 http://dx.doi.org/10.1371/journal.pone.0027415 |
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author | Izaks, Gerbrand J. Gansevoort, Ron T. van der Knaap, Aafke M. Navis, Gerjan Dullaart, Robin P. F. Slaets, Joris P. J. |
author_facet | Izaks, Gerbrand J. Gansevoort, Ron T. van der Knaap, Aafke M. Navis, Gerjan Dullaart, Robin P. F. Slaets, Joris P. J. |
author_sort | Izaks, Gerbrand J. |
collection | PubMed |
description | APOE genotype is associated with the risk of Alzheimer's disease. In the present study, we investigated whether APOE genotype was associated with cognitive function in predominantly middle-aged persons. In a population-based cohort of 4,135 persons aged 35 to 82 years (mean age (SD), 55 (12) years), cognitive function was measured with the Ruff Figural Fluency Test (RFFT; worst score, 0 points; best score, 175 points). APOE genotype (rs429358 and rs7412) was determined by polymerase chain reaction. The mean RFFT score (SD) of the total cohort was 69 (26) points. Unadjusted, the mean RFFT score in homozygous APOE ε4 carriers was 4.66 points lower than in noncarriers (95% confidence interval, -9.84 to 0.51; p = 0.08). After adjustment for age and other risk factors, the mean RFFT score in homozygous APOE ε4 carriers was 5.24 points lower than in noncarriers (95% confidence interval, -9.41 to -1.07; p = 0.01). The difference in RFFT score was not dependent on age. There was no difference in RFFT score between heterozygous APOE ε4 carriers and noncarriers. The results indicated that homozygous APOE ε4 carriers aged 35 years or older had worse cognitive function than heterozygous carriers and noncarriers. |
format | Online Article Text |
id | pubmed-3215744 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-32157442011-11-21 The Association of APOE Genotype with Cognitive Function in Persons Aged 35 Years or Older Izaks, Gerbrand J. Gansevoort, Ron T. van der Knaap, Aafke M. Navis, Gerjan Dullaart, Robin P. F. Slaets, Joris P. J. PLoS One Research Article APOE genotype is associated with the risk of Alzheimer's disease. In the present study, we investigated whether APOE genotype was associated with cognitive function in predominantly middle-aged persons. In a population-based cohort of 4,135 persons aged 35 to 82 years (mean age (SD), 55 (12) years), cognitive function was measured with the Ruff Figural Fluency Test (RFFT; worst score, 0 points; best score, 175 points). APOE genotype (rs429358 and rs7412) was determined by polymerase chain reaction. The mean RFFT score (SD) of the total cohort was 69 (26) points. Unadjusted, the mean RFFT score in homozygous APOE ε4 carriers was 4.66 points lower than in noncarriers (95% confidence interval, -9.84 to 0.51; p = 0.08). After adjustment for age and other risk factors, the mean RFFT score in homozygous APOE ε4 carriers was 5.24 points lower than in noncarriers (95% confidence interval, -9.41 to -1.07; p = 0.01). The difference in RFFT score was not dependent on age. There was no difference in RFFT score between heterozygous APOE ε4 carriers and noncarriers. The results indicated that homozygous APOE ε4 carriers aged 35 years or older had worse cognitive function than heterozygous carriers and noncarriers. Public Library of Science 2011-11-14 /pmc/articles/PMC3215744/ /pubmed/22110642 http://dx.doi.org/10.1371/journal.pone.0027415 Text en Izaks et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Izaks, Gerbrand J. Gansevoort, Ron T. van der Knaap, Aafke M. Navis, Gerjan Dullaart, Robin P. F. Slaets, Joris P. J. The Association of APOE Genotype with Cognitive Function in Persons Aged 35 Years or Older |
title | The Association of APOE Genotype with Cognitive Function in Persons Aged 35 Years or Older |
title_full | The Association of APOE Genotype with Cognitive Function in Persons Aged 35 Years or Older |
title_fullStr | The Association of APOE Genotype with Cognitive Function in Persons Aged 35 Years or Older |
title_full_unstemmed | The Association of APOE Genotype with Cognitive Function in Persons Aged 35 Years or Older |
title_short | The Association of APOE Genotype with Cognitive Function in Persons Aged 35 Years or Older |
title_sort | association of apoe genotype with cognitive function in persons aged 35 years or older |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215744/ https://www.ncbi.nlm.nih.gov/pubmed/22110642 http://dx.doi.org/10.1371/journal.pone.0027415 |
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