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Domain architecture conservation in orthologs
BACKGROUND: As orthologous proteins are expected to retain function more often than other homologs, they are often used for functional annotation transfer between species. However, ortholog identification methods do not take into account changes in domain architecture, which are likely to modify a p...
Autores principales: | Forslund, Kristoffer, Pekkari, Isabella, Sonnhammer, Erik LL |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215765/ https://www.ncbi.nlm.nih.gov/pubmed/21819573 http://dx.doi.org/10.1186/1471-2105-12-326 |
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