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Domain architecture conservation in orthologs

BACKGROUND: As orthologous proteins are expected to retain function more often than other homologs, they are often used for functional annotation transfer between species. However, ortholog identification methods do not take into account changes in domain architecture, which are likely to modify a p...

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Detalles Bibliográficos
Autores principales: Forslund, Kristoffer, Pekkari, Isabella, Sonnhammer, Erik LL
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215765/
https://www.ncbi.nlm.nih.gov/pubmed/21819573
http://dx.doi.org/10.1186/1471-2105-12-326

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