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A hidden Markov model to assess drug-induced sleep fragmentation in the telemetered rat

Drug-induced sleep fragmentation can cause sleep disturbances either via their intended pharmacological action or as a side effect. Examples of disturbances include excessive daytime sleepiness, insomnia and nightmares. Developing drugs without these side effects requires insight into the mechanisms...

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Detalles Bibliográficos
Autores principales:	Diack, C., Ackaert, O., Ploeger, B. A., van der Graaf, P. H., Gurrell, R., Ivarsson, M., Fairman, D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215869/ https://www.ncbi.nlm.nih.gov/pubmed/21909798 http://dx.doi.org/10.1007/s10928-011-9215-3

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