Frequent loss of the AXIN1 locus but absence of AXIN1 gene mutations in adenocarcinomas of the gastro-oesophageal junction with nuclear β-catenin expression

Up to 60% of gastro-oesophageal junction (GEJ) adenocarcinomas show nuclear β-catenin expression, pointing to activated T-cell factor (TCF)/β-catenin-driven gene transcription. We demonstrate in five human GEJ adenocarcinoma cell lines that nuclear β-catenin expression indeed correlates with enhance...

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Detalles Bibliográficos
Autores principales: Koppert, L B, van der Velden, A W, van de Wetering, M, Abbou, M, van den Ouweland, A M W, Tilanus, H W, Wijnhoven, B P L, Dinjens, W N M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215949/
https://www.ncbi.nlm.nih.gov/pubmed/14970870
http://dx.doi.org/10.1038/sj.bjc.6601589

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