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The human epidermal growth factor receptor (EGFR) gene in European patients with advanced colorectal cancer harbors infrequent mutations in its tyrosine kinase domain

BACKGROUND: The epidermal growth factor receptor (EGFR), a member of the ErbB family of receptors, is a transmembrane tyrosine kinase (TK) activated by the binding of extracellular ligands of the EGF-family and involved in triggering the MAPK signaling pathway, which leads to cell proliferation. Mut...

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Detalles Bibliográficos
Autores principales:	Metzger, Brigitte, Chambeau, Laetitia, Begon, Dominique Y, Faber, Carlo, Kayser, Jacques, Berchem, Guy, Pauly, Marc, Boniver, Jacques, Delvenne, Philippe, Dicato, Mario, Wenner, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215960/ https://www.ncbi.nlm.nih.gov/pubmed/22026926 http://dx.doi.org/10.1186/1471-2350-12-144

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