Cardiomyocyte Triglyceride Accumulation and Reduced Ventricular Function in Mice with Obesity Reflect Increased Long Chain Fatty Acid Uptake and De Novo Fatty Acid Synthesis

A nonarteriosclerotic cardiomyopathy is increasingly seen in obese patients. Seeking a rodent model, we studied cardiac histology, function, cardiomyocyte fatty acid uptake, and transporter gene expression in male C57BL/6J control mice and three obesity groups: similar mice fed a high-fat diet (HFD)...

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Detalles Bibliográficos
Autores principales: Ge, Fengxia, Hu, Chunguang, Hyodo, Eiichi, Arai, Kotaro, Zhou, Shengli, Lobdell IV, Harrison, Walewski, José L., Homma, Shunichi, Berk, Paul D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216284/
https://www.ncbi.nlm.nih.gov/pubmed/22132320
http://dx.doi.org/10.1155/2012/205648

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