Cargando…

Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species

Unraveling the gene regulatory networks that govern development and function of the mammalian heart is critical for the rational design of therapeutic interventions in human heart disease. Using the Drosophila heart as a platform for identifying novel gene interactions leading to heart disease, we f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qian, Li, Wythe, Joshua D., Liu, Jiandong, Cartry, Jerome, Vogler, Georg, Mohapatra, Bhagyalaxmi, Otway, Robyn T., Huang, Yu, King, Isabelle N., Maillet, Marjorie, Zheng, Yi, Crawley, Timothy, Taghli-Lamallem, Ouarda, Semsarian, Christopher, Dunwoodie, Sally, Winlaw, David, Harvey, Richard P., Fatkin, Diane, Towbin, Jeffrey A., Molkentin, Jeffery D., Srivastava, Deepak, Ocorr, Karen, Bruneau, Benoit G., Bodmer, Rolf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2011
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216339/ https://www.ncbi.nlm.nih.gov/pubmed/21690310 http://dx.doi.org/10.1083/jcb.201006114

Ejemplares similares

Drosophila in the Heart of Understanding Cardiac Diseases: Modeling Channelopathies and Cardiomyopathies in the Fruitfly
por: Taghli-Lamallem, Ouarda, et al.
Publicado: (2016)

Over-Expression of DSCAM and COL6A2 Cooperatively Generates Congenital Heart Defects
por: Grossman, Tamar R., et al.
Publicado: (2011)

Cdc42 and Tinman march to the same beat
por: Short, Ben
Publicado: (2011)

Tinman Regulates NetrinB in the Cardioblasts of the Drosophila Dorsal Vessel
por: Asadzadeh, Jamshid, et al.
Publicado: (2016)

Post-Dilatation of New-Generation Self-Expandable Transcatheter Aortic Valves Does Not Increase Atrioventricular Conduction Abnormalities
por: Massoullié, Grégoire, et al.
Publicado: (2023)

The Unc-5 Receptor Is Directly Regulated by Tinman in the Developing Drosophila Dorsal Vessel
por: Asadzadeh, Jamshid, et al.
Publicado: (2015)

Heuristic Methods for Finding Pathogenic Variants in Gene Coding Sequences
por: Ohanian, Monique, et al.
Publicado: (2012)

Genome-Wide Screens for In Vivo Tinman Binding Sites Identify Cardiac Enhancers with Diverse Functional Architectures
por: Jin, Hong, et al.
Publicado: (2013)

Overexpression of Kif1A in the Developing Drosophila Heart Causes Valvar and Contractility Defects: Implications for Human Congenital Heart Disease
por: Akasaka, Takeshi, et al.
Publicado: (2020)

The Drosophila Transcription Factors Tinman and Pannier Activate and Collaborate with Myocyte Enhancer Factor-2 to Promote Heart Cell Fate
por: Lovato, TyAnna L., et al.
Publicado: (2015)

Nkx-2.5 Regulates MDR1 Expression via Its Upstream Promoter in Breast Cancer Cells
por: Lim, Jung-Suk, et al.
Publicado: (2019)

Complex SUMO-1 Regulation of Cardiac Transcription Factor Nkx2-5
por: Costa, Mauro W., et al.
Publicado: (2011)

Expression patterns of cardiac aging in Drosophila
por: Cannon, Leah, et al.
Publicado: (2017)

SPARC–Dependent Cardiomyopathy in Drosophila
por: Hartley, Paul S., et al.
Publicado: (2016)

Characterization of two functional NKX3.1 binding sites upstream of the PCAN1 gene that are involved in the positive regulation of PCAN1 gene transcription
por: Liu, Wenwen, et al.
Publicado: (2008)

NKX2-5 Regulates the Expression of β-Catenin and GATA4 in Ventricular Myocytes
por: Riazi, Ali M., et al.
Publicado: (2009)

VPOT: A Customizable Variant Prioritization Ordering Tool for Annotated Variants
por: Ip, Eddie, et al.
Publicado: (2019)

Genetic Variation for Cardiac Dysfunction in Drosophila
por: Ocorr, Karen A., et al.
Publicado: (2007)

Nkx2.7 and Nkx2.5 Function Redundantly and Are Required for Cardiac Morphogenesis of Zebrafish Embryos
por: Tu, Chi-Tang, et al.
Publicado: (2009)

Cdc42 and formin activity control non-muscle myosin dynamics during Drosophila heart morphogenesis
por: Vogler, Georg, et al.
Publicado: (2014)

The UNC-45 Chaperone Is Critical for Establishing Myosin-Based Myofibrillar Organization and Cardiac Contractility in the Drosophila Heart Model
por: Melkani, Girish C., et al.
Publicado: (2011)

Multiplexin Promotes Heart but Not Aorta Morphogenesis by Polarized Enhancement of Slit/Robo Activity at the Heart Lumen
por: Harpaz, Nofar, et al.
Publicado: (2013)

Combined Mutation Screening of NKX2-5, GATA4, and TBX5 in Congenital Heart Disease: Multiple Heterozygosity and Novel Mutations
por: Granados-Riveron, Javier T, et al.
Publicado: (2012)

NKX2-5 mutations causative for congenital heart disease retain functionality and are directed to hundreds of targets
por: Bouveret, Romaric, et al.
Publicado: (2015)

ROS Regulate Cardiac Function via a Distinct Paracrine Mechanism
por: Lim, Hui-Ying, et al.
Publicado: (2014)

Investigation of Association between PFO Complicated by Cryptogenic Stroke and a Common Variant of the Cardiac Transcription Factor GATA4
por: Moradi Marjaneh, Mahdi, et al.
Publicado: (2011)

The NANCI–Nkx2.1 gene duplex buffers Nkx2.1 expression to maintain lung development and homeostasis
por: Herriges, Michael J., et al.
Publicado: (2017)

NKL Homeobox Genes NKX2-3 and NKX2-4 Deregulate Megakaryocytic-Erythroid Cell Differentiation in AML
por: Nagel, Stefan, et al.
Publicado: (2021)

Calreticulin signals upstream of calcineurin and MEF2C in a critical Ca(2+)-dependent signaling cascade
por: Lynch, Jeffrey, et al.
Publicado: (2005)

Cellular Mechanisms of Drosophila Heart Morphogenesis
por: Vogler, Georg, et al.
Publicado: (2015)

Upstream
por: Evans, Virginia, 1945-
Publicado: (2005)

Upstream
por: Evans, Virginia, 1945-
Publicado: (2005)

Upstream Tracker Upgrade Status of the Upstream Tracker
por: Andreou, Dimitra
Publicado: (2022)

The Role of Nkx3.1 in Cancers and Stemness
por: Antao, Ainsley Mike, et al.
Publicado: (2021)

Expression of Sumoylation Deficient Nkx2.5 Mutant in Nkx2.5 Haploinsufficient Mice Leads to Congenital Heart Defects
por: Kim, Eun Young, et al.
Publicado: (2011)

Benchmarking the Effectiveness and Accuracy of Multiple Mitochondrial DNA Variant Callers: Practical Implications for Clinical Application
por: Ip, Eddie K. K., et al.
Publicado: (2022)

Systemic and heart autonomous effects of sphingosine Δ4 desaturase deficiency in lipotoxic cardiac pathophysiology
por: Walls, Stanley M., et al.
Publicado: (2020)

Nkx2.2 and Nkx2.9 Are the Key Regulators to Determine Cell Fate of Branchial and Visceral Motor Neurons in Caudal Hindbrain
por: Jarrar, Wassan, et al.
Publicado: (2015)

nkx2.1 and nkx2.4 genes function partially redundant during development of the zebrafish hypothalamus, preoptic region, and pallidum
por: Manoli, Martha, et al.
Publicado: (2014)

Upstream : pre-intermediate
por: Evans, Virginia, 1945-
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_72iv21upciv2d3rtghgf5pi3af