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Smouldering Malignant Melanoma and Metastatic Dormancy: An Update and Review

The fund of knowledge regarding the versatility of presentation of MM metastases is still quite incomplete. The recent literature pertaining to the current understanding of the mechanisms underlying two special features of MM metastasis is reviewed. On the one hand, a long disease-free interval (MM...

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Autores principales: Piérard, Gérald E., Piérard-Franchimont, Claudine, Reginster, Marie-Annick, Quatresooz, Pascale
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216350/
https://www.ncbi.nlm.nih.gov/pubmed/22110487
http://dx.doi.org/10.1155/2012/461278
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author Piérard, Gérald E.
Piérard-Franchimont, Claudine
Reginster, Marie-Annick
Quatresooz, Pascale
author_facet Piérard, Gérald E.
Piérard-Franchimont, Claudine
Reginster, Marie-Annick
Quatresooz, Pascale
author_sort Piérard, Gérald E.
collection PubMed
description The fund of knowledge regarding the versatility of presentation of MM metastases is still quite incomplete. The recent literature pertaining to the current understanding of the mechanisms underlying two special features of MM metastasis is reviewed. On the one hand, a long disease-free interval (MM dormancy) may occur before the surge of overt metastases. On the other hand, the so-called MM smouldering phenomenon refers to the condition where regional metastases wax and wane for long periods of time on restricted skin regions. It is important to emphasize that local micrometastases often predict sentinel lymph node involvement but may not reflect progression of the primary MM to full-blown visceral metastatic competence. It is likely that a combination of factors impacts the versatile MM metastasic progression. Among the main factors, one has to mention the phenotypic heterogeneity and variability in the phenotype of MM cells, the presence of MM stem cells and MM cells engaged in an amplification proliferation pool, as well as the host immune response, and possibly the induction of a particular stromal structure and vascularity.
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spelling pubmed-32163502011-11-22 Smouldering Malignant Melanoma and Metastatic Dormancy: An Update and Review Piérard, Gérald E. Piérard-Franchimont, Claudine Reginster, Marie-Annick Quatresooz, Pascale Dermatol Res Pract Review Article The fund of knowledge regarding the versatility of presentation of MM metastases is still quite incomplete. The recent literature pertaining to the current understanding of the mechanisms underlying two special features of MM metastasis is reviewed. On the one hand, a long disease-free interval (MM dormancy) may occur before the surge of overt metastases. On the other hand, the so-called MM smouldering phenomenon refers to the condition where regional metastases wax and wane for long periods of time on restricted skin regions. It is important to emphasize that local micrometastases often predict sentinel lymph node involvement but may not reflect progression of the primary MM to full-blown visceral metastatic competence. It is likely that a combination of factors impacts the versatile MM metastasic progression. Among the main factors, one has to mention the phenotypic heterogeneity and variability in the phenotype of MM cells, the presence of MM stem cells and MM cells engaged in an amplification proliferation pool, as well as the host immune response, and possibly the induction of a particular stromal structure and vascularity. Hindawi Publishing Corporation 2012 2011-11-02 /pmc/articles/PMC3216350/ /pubmed/22110487 http://dx.doi.org/10.1155/2012/461278 Text en Copyright © 2012 Gérald E. Piérard et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Piérard, Gérald E.
Piérard-Franchimont, Claudine
Reginster, Marie-Annick
Quatresooz, Pascale
Smouldering Malignant Melanoma and Metastatic Dormancy: An Update and Review
title Smouldering Malignant Melanoma and Metastatic Dormancy: An Update and Review
title_full Smouldering Malignant Melanoma and Metastatic Dormancy: An Update and Review
title_fullStr Smouldering Malignant Melanoma and Metastatic Dormancy: An Update and Review
title_full_unstemmed Smouldering Malignant Melanoma and Metastatic Dormancy: An Update and Review
title_short Smouldering Malignant Melanoma and Metastatic Dormancy: An Update and Review
title_sort smouldering malignant melanoma and metastatic dormancy: an update and review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216350/
https://www.ncbi.nlm.nih.gov/pubmed/22110487
http://dx.doi.org/10.1155/2012/461278
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