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Perinatal Programming of Asthma: The Role of Gut Microbiota
Perinatal programming, a dominant theory for the origins of cardiovascular disease, proposes that environmental stimuli influence developmental pathways during critical periods of prenatal and postnatal development, inducing permanent changes in metabolism. In this paper, we present evidence for the...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216351/ https://www.ncbi.nlm.nih.gov/pubmed/22110540 http://dx.doi.org/10.1155/2012/932072 |
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author | Azad, Meghan B. Kozyrskyj, Anita L. |
author_facet | Azad, Meghan B. Kozyrskyj, Anita L. |
author_sort | Azad, Meghan B. |
collection | PubMed |
description | Perinatal programming, a dominant theory for the origins of cardiovascular disease, proposes that environmental stimuli influence developmental pathways during critical periods of prenatal and postnatal development, inducing permanent changes in metabolism. In this paper, we present evidence for the perinatal programming of asthma via the intestinal microbiome. While epigenetic mechanisms continue to provide new explanations for the programming hypothesis of asthma development, it is increasingly apparent that the intestinal microbiota plays an independent and potentially interactive role. Commensal gut bacteria are essential to immune system development, and exposures disrupting the infant gut microbiota have been linked to asthma. This paper summarizes the recent findings that implicate caesarean delivery, breastfeeding, perinatal stress, probiotics, and antibiotics as modifiers of infant gut microbiota in the development of asthma. |
format | Online Article Text |
id | pubmed-3216351 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32163512011-11-22 Perinatal Programming of Asthma: The Role of Gut Microbiota Azad, Meghan B. Kozyrskyj, Anita L. Clin Dev Immunol Review Article Perinatal programming, a dominant theory for the origins of cardiovascular disease, proposes that environmental stimuli influence developmental pathways during critical periods of prenatal and postnatal development, inducing permanent changes in metabolism. In this paper, we present evidence for the perinatal programming of asthma via the intestinal microbiome. While epigenetic mechanisms continue to provide new explanations for the programming hypothesis of asthma development, it is increasingly apparent that the intestinal microbiota plays an independent and potentially interactive role. Commensal gut bacteria are essential to immune system development, and exposures disrupting the infant gut microbiota have been linked to asthma. This paper summarizes the recent findings that implicate caesarean delivery, breastfeeding, perinatal stress, probiotics, and antibiotics as modifiers of infant gut microbiota in the development of asthma. Hindawi Publishing Corporation 2012 2011-11-03 /pmc/articles/PMC3216351/ /pubmed/22110540 http://dx.doi.org/10.1155/2012/932072 Text en Copyright © 2012 M. B. Azad and A. L. Kozyrskyj. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Azad, Meghan B. Kozyrskyj, Anita L. Perinatal Programming of Asthma: The Role of Gut Microbiota |
title | Perinatal Programming of Asthma: The Role of Gut Microbiota |
title_full | Perinatal Programming of Asthma: The Role of Gut Microbiota |
title_fullStr | Perinatal Programming of Asthma: The Role of Gut Microbiota |
title_full_unstemmed | Perinatal Programming of Asthma: The Role of Gut Microbiota |
title_short | Perinatal Programming of Asthma: The Role of Gut Microbiota |
title_sort | perinatal programming of asthma: the role of gut microbiota |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216351/ https://www.ncbi.nlm.nih.gov/pubmed/22110540 http://dx.doi.org/10.1155/2012/932072 |
work_keys_str_mv | AT azadmeghanb perinatalprogrammingofasthmatheroleofgutmicrobiota AT kozyrskyjanital perinatalprogrammingofasthmatheroleofgutmicrobiota |