Cargando…

Perinatal Programming of Asthma: The Role of Gut Microbiota

Perinatal programming, a dominant theory for the origins of cardiovascular disease, proposes that environmental stimuli influence developmental pathways during critical periods of prenatal and postnatal development, inducing permanent changes in metabolism. In this paper, we present evidence for the...

Descripción completa

Detalles Bibliográficos
Autores principales: Azad, Meghan B., Kozyrskyj, Anita L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216351/
https://www.ncbi.nlm.nih.gov/pubmed/22110540
http://dx.doi.org/10.1155/2012/932072
_version_ 1782216501518925824
author Azad, Meghan B.
Kozyrskyj, Anita L.
author_facet Azad, Meghan B.
Kozyrskyj, Anita L.
author_sort Azad, Meghan B.
collection PubMed
description Perinatal programming, a dominant theory for the origins of cardiovascular disease, proposes that environmental stimuli influence developmental pathways during critical periods of prenatal and postnatal development, inducing permanent changes in metabolism. In this paper, we present evidence for the perinatal programming of asthma via the intestinal microbiome. While epigenetic mechanisms continue to provide new explanations for the programming hypothesis of asthma development, it is increasingly apparent that the intestinal microbiota plays an independent and potentially interactive role. Commensal gut bacteria are essential to immune system development, and exposures disrupting the infant gut microbiota have been linked to asthma. This paper summarizes the recent findings that implicate caesarean delivery, breastfeeding, perinatal stress, probiotics, and antibiotics as modifiers of infant gut microbiota in the development of asthma.
format Online
Article
Text
id pubmed-3216351
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-32163512011-11-22 Perinatal Programming of Asthma: The Role of Gut Microbiota Azad, Meghan B. Kozyrskyj, Anita L. Clin Dev Immunol Review Article Perinatal programming, a dominant theory for the origins of cardiovascular disease, proposes that environmental stimuli influence developmental pathways during critical periods of prenatal and postnatal development, inducing permanent changes in metabolism. In this paper, we present evidence for the perinatal programming of asthma via the intestinal microbiome. While epigenetic mechanisms continue to provide new explanations for the programming hypothesis of asthma development, it is increasingly apparent that the intestinal microbiota plays an independent and potentially interactive role. Commensal gut bacteria are essential to immune system development, and exposures disrupting the infant gut microbiota have been linked to asthma. This paper summarizes the recent findings that implicate caesarean delivery, breastfeeding, perinatal stress, probiotics, and antibiotics as modifiers of infant gut microbiota in the development of asthma. Hindawi Publishing Corporation 2012 2011-11-03 /pmc/articles/PMC3216351/ /pubmed/22110540 http://dx.doi.org/10.1155/2012/932072 Text en Copyright © 2012 M. B. Azad and A. L. Kozyrskyj. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Azad, Meghan B.
Kozyrskyj, Anita L.
Perinatal Programming of Asthma: The Role of Gut Microbiota
title Perinatal Programming of Asthma: The Role of Gut Microbiota
title_full Perinatal Programming of Asthma: The Role of Gut Microbiota
title_fullStr Perinatal Programming of Asthma: The Role of Gut Microbiota
title_full_unstemmed Perinatal Programming of Asthma: The Role of Gut Microbiota
title_short Perinatal Programming of Asthma: The Role of Gut Microbiota
title_sort perinatal programming of asthma: the role of gut microbiota
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216351/
https://www.ncbi.nlm.nih.gov/pubmed/22110540
http://dx.doi.org/10.1155/2012/932072
work_keys_str_mv AT azadmeghanb perinatalprogrammingofasthmatheroleofgutmicrobiota
AT kozyrskyjanital perinatalprogrammingofasthmatheroleofgutmicrobiota