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Association between Serum Uric Acid Levels and Diabetes Mellitus

Serum uric acid has been shown to be associated with cardiovascular disease, hypertension, and chronic kidney disease in previous studies. However, few studies have examined the association between serum uric acid and diabetes mellitus and their findings are not consistent. Therefore, we examined th...

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Autores principales: Bandaru, Pavani, Shankar, Anoop
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216382/
https://www.ncbi.nlm.nih.gov/pubmed/22114591
http://dx.doi.org/10.1155/2011/604715
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author Bandaru, Pavani
Shankar, Anoop
author_facet Bandaru, Pavani
Shankar, Anoop
author_sort Bandaru, Pavani
collection PubMed
description Serum uric acid has been shown to be associated with cardiovascular disease, hypertension, and chronic kidney disease in previous studies. However, few studies have examined the association between serum uric acid and diabetes mellitus and their findings are not consistent. Therefore, we examined the association between serum uric acid levels and diabetes mellitus in participants from the third National Health and Nutrition Examination Survey (n = 18, 825, 52.5% women). Serum uric acid levels were categorized into quartiles. Diabetes mellitus was defined as fasting glucose ≥126 mg/dL, nonfasting glucose ≥200 mg/dL, or use of oral hypoglycemic medication or insulin (n = 395). In multivariable logistic regression models, we found that higher serum uric acid levels were inversely associated with diabetes mellitus after adjusting for age, sex, race/ethnicity, education, smoking, alcohol intake, body mass index, hypertension, and serum cholesterol. Compared to quartile 1 of serum uric acid, the odds ratio (95% confidence interval) of diabetes mellitus was 0.48 (0.35–0.66; P trend <0.0001). The results were consistent in subgroup analysis by gender and hypertension status. Higher serum uric acid levels were inversely associated with diabetes mellitus in a representative sample of US adults.
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spelling pubmed-32163822011-11-23 Association between Serum Uric Acid Levels and Diabetes Mellitus Bandaru, Pavani Shankar, Anoop Int J Endocrinol Clinical Study Serum uric acid has been shown to be associated with cardiovascular disease, hypertension, and chronic kidney disease in previous studies. However, few studies have examined the association between serum uric acid and diabetes mellitus and their findings are not consistent. Therefore, we examined the association between serum uric acid levels and diabetes mellitus in participants from the third National Health and Nutrition Examination Survey (n = 18, 825, 52.5% women). Serum uric acid levels were categorized into quartiles. Diabetes mellitus was defined as fasting glucose ≥126 mg/dL, nonfasting glucose ≥200 mg/dL, or use of oral hypoglycemic medication or insulin (n = 395). In multivariable logistic regression models, we found that higher serum uric acid levels were inversely associated with diabetes mellitus after adjusting for age, sex, race/ethnicity, education, smoking, alcohol intake, body mass index, hypertension, and serum cholesterol. Compared to quartile 1 of serum uric acid, the odds ratio (95% confidence interval) of diabetes mellitus was 0.48 (0.35–0.66; P trend <0.0001). The results were consistent in subgroup analysis by gender and hypertension status. Higher serum uric acid levels were inversely associated with diabetes mellitus in a representative sample of US adults. Hindawi Publishing Corporation 2011 2011-11-02 /pmc/articles/PMC3216382/ /pubmed/22114591 http://dx.doi.org/10.1155/2011/604715 Text en Copyright © 2011 P. Bandaru and A. Shankar. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Bandaru, Pavani
Shankar, Anoop
Association between Serum Uric Acid Levels and Diabetes Mellitus
title Association between Serum Uric Acid Levels and Diabetes Mellitus
title_full Association between Serum Uric Acid Levels and Diabetes Mellitus
title_fullStr Association between Serum Uric Acid Levels and Diabetes Mellitus
title_full_unstemmed Association between Serum Uric Acid Levels and Diabetes Mellitus
title_short Association between Serum Uric Acid Levels and Diabetes Mellitus
title_sort association between serum uric acid levels and diabetes mellitus
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216382/
https://www.ncbi.nlm.nih.gov/pubmed/22114591
http://dx.doi.org/10.1155/2011/604715
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