Mutations within the tyrosine kinase domain of EGFR gene specifically occur in lung adenocarcinoma patients with a low exposure of tobacco smoking

Somatically acquired mutations in the epidermal growth factor receptor (EGFR) gene in lung cancer are associated with significant clinical responses to gefitinib, a tyrosine kinase inhibitor that targets EGFR. We screened the EGFR in 469 resected tumours of patients with lung cancer, which included...

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Detalles Bibliográficos
Autores principales: Sugio, K, Uramoto, H, Ono, K, Oyama, T, Hanagiri, T, Sugaya, M, Ichiki, Y, So, T, Nakata, S, Morita, M, Yasumoto, K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2006
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216424/
https://www.ncbi.nlm.nih.gov/pubmed/16552419
http://dx.doi.org/10.1038/sj.bjc.6603040

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