Zic2 hypomorphic mutant mice as a schizophrenia model and ZIC2 mutations identified in schizophrenia patients

ZIC2 is a causal gene for holoprosencephaly and encodes a zinc-finger-type transcriptional regulator. We characterized Zic2(kd/+) mice with a moderate (40%) reduction in Zic2 expression. Zic2(kd/+) mice showed increased locomotor activity in novel environments, cognitive and sensorimotor gating dysf...

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Detalles Bibliográficos
Autores principales: Hatayama, Minoru, Ishiguro, Akira, Iwayama, Yoshimi, Takashima, Noriko, Sakoori, Kazuto, Toyota, Tomoko, Nozaki, Yayoi, Odaka, Yuri S., Yamada, Kazuyuki, Yoshikawa, Takeo, Aruga, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216504/
https://www.ncbi.nlm.nih.gov/pubmed/22355535
http://dx.doi.org/10.1038/srep00016

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