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Plasticity and rectangularity in survival curves
Living systems inevitably undergo a progressive deterioration of physiological function with age and an increase of vulnerability to disease and death. To maintain health and survival, living systems should optimize survival strategies with adaptive interactions among molecules, cells, organs, indiv...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216589/ https://www.ncbi.nlm.nih.gov/pubmed/22355622 http://dx.doi.org/10.1038/srep00104 |
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author | Weon, Byung Mook Je, Jung Ho |
author_facet | Weon, Byung Mook Je, Jung Ho |
author_sort | Weon, Byung Mook |
collection | PubMed |
description | Living systems inevitably undergo a progressive deterioration of physiological function with age and an increase of vulnerability to disease and death. To maintain health and survival, living systems should optimize survival strategies with adaptive interactions among molecules, cells, organs, individuals, and environments, which arises plasticity in survival curves of living systems. In general, survival dynamics in a population is mathematically depicted by a survival rate, which monotonically changes from 1 to 0 with age. It would be then useful to find an adequate function to describe complicated survival dynamics. Here we describe a flexible survival function, derived from the stretched exponential function by adopting an age-dependent shaping exponent. We note that the exponent is associated with the fractal-like scaling in cumulative mortality rate. The survival function well depicts general features in survival curves; healthy populations exhibit plasticity and evolve towards rectangular-like survival curves, as examples in humans or laboratory animals. |
format | Online Article Text |
id | pubmed-3216589 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-32165892011-12-22 Plasticity and rectangularity in survival curves Weon, Byung Mook Je, Jung Ho Sci Rep Article Living systems inevitably undergo a progressive deterioration of physiological function with age and an increase of vulnerability to disease and death. To maintain health and survival, living systems should optimize survival strategies with adaptive interactions among molecules, cells, organs, individuals, and environments, which arises plasticity in survival curves of living systems. In general, survival dynamics in a population is mathematically depicted by a survival rate, which monotonically changes from 1 to 0 with age. It would be then useful to find an adequate function to describe complicated survival dynamics. Here we describe a flexible survival function, derived from the stretched exponential function by adopting an age-dependent shaping exponent. We note that the exponent is associated with the fractal-like scaling in cumulative mortality rate. The survival function well depicts general features in survival curves; healthy populations exhibit plasticity and evolve towards rectangular-like survival curves, as examples in humans or laboratory animals. Nature Publishing Group 2011-09-28 /pmc/articles/PMC3216589/ /pubmed/22355622 http://dx.doi.org/10.1038/srep00104 Text en Copyright © 2011, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareALike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
spellingShingle | Article Weon, Byung Mook Je, Jung Ho Plasticity and rectangularity in survival curves |
title | Plasticity and rectangularity in survival curves |
title_full | Plasticity and rectangularity in survival curves |
title_fullStr | Plasticity and rectangularity in survival curves |
title_full_unstemmed | Plasticity and rectangularity in survival curves |
title_short | Plasticity and rectangularity in survival curves |
title_sort | plasticity and rectangularity in survival curves |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216589/ https://www.ncbi.nlm.nih.gov/pubmed/22355622 http://dx.doi.org/10.1038/srep00104 |
work_keys_str_mv | AT weonbyungmook plasticityandrectangularityinsurvivalcurves AT jejungho plasticityandrectangularityinsurvivalcurves |