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Plasticity and rectangularity in survival curves

Living systems inevitably undergo a progressive deterioration of physiological function with age and an increase of vulnerability to disease and death. To maintain health and survival, living systems should optimize survival strategies with adaptive interactions among molecules, cells, organs, indiv...

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Detalles Bibliográficos
Autores principales: Weon, Byung Mook, Je, Jung Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216589/
https://www.ncbi.nlm.nih.gov/pubmed/22355622
http://dx.doi.org/10.1038/srep00104
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author Weon, Byung Mook
Je, Jung Ho
author_facet Weon, Byung Mook
Je, Jung Ho
author_sort Weon, Byung Mook
collection PubMed
description Living systems inevitably undergo a progressive deterioration of physiological function with age and an increase of vulnerability to disease and death. To maintain health and survival, living systems should optimize survival strategies with adaptive interactions among molecules, cells, organs, individuals, and environments, which arises plasticity in survival curves of living systems. In general, survival dynamics in a population is mathematically depicted by a survival rate, which monotonically changes from 1 to 0 with age. It would be then useful to find an adequate function to describe complicated survival dynamics. Here we describe a flexible survival function, derived from the stretched exponential function by adopting an age-dependent shaping exponent. We note that the exponent is associated with the fractal-like scaling in cumulative mortality rate. The survival function well depicts general features in survival curves; healthy populations exhibit plasticity and evolve towards rectangular-like survival curves, as examples in humans or laboratory animals.
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spelling pubmed-32165892011-12-22 Plasticity and rectangularity in survival curves Weon, Byung Mook Je, Jung Ho Sci Rep Article Living systems inevitably undergo a progressive deterioration of physiological function with age and an increase of vulnerability to disease and death. To maintain health and survival, living systems should optimize survival strategies with adaptive interactions among molecules, cells, organs, individuals, and environments, which arises plasticity in survival curves of living systems. In general, survival dynamics in a population is mathematically depicted by a survival rate, which monotonically changes from 1 to 0 with age. It would be then useful to find an adequate function to describe complicated survival dynamics. Here we describe a flexible survival function, derived from the stretched exponential function by adopting an age-dependent shaping exponent. We note that the exponent is associated with the fractal-like scaling in cumulative mortality rate. The survival function well depicts general features in survival curves; healthy populations exhibit plasticity and evolve towards rectangular-like survival curves, as examples in humans or laboratory animals. Nature Publishing Group 2011-09-28 /pmc/articles/PMC3216589/ /pubmed/22355622 http://dx.doi.org/10.1038/srep00104 Text en Copyright © 2011, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareALike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Article
Weon, Byung Mook
Je, Jung Ho
Plasticity and rectangularity in survival curves
title Plasticity and rectangularity in survival curves
title_full Plasticity and rectangularity in survival curves
title_fullStr Plasticity and rectangularity in survival curves
title_full_unstemmed Plasticity and rectangularity in survival curves
title_short Plasticity and rectangularity in survival curves
title_sort plasticity and rectangularity in survival curves
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216589/
https://www.ncbi.nlm.nih.gov/pubmed/22355622
http://dx.doi.org/10.1038/srep00104
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