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An N-methyl-d-aspartate receptor agonist facilitates sleep-independent synaptic plasticity associated with working memory capacity enhancement

Working memory (WM) capacity improvement is impacted by sleep, and possibly by N-methyl-D-aspartate (NMDA) agonists such as D-cycloserine (DCS), which also affects procedural skill performance. However, the mechanisms behind these relationships are not well understood. In order to investigate the ne...

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Autores principales: Kuriyama, Kenichi, Honma, Motoyasu, Shimazaki, Miyuki, Horie, Michiko, Yoshiike, Takuya, Koyama, Sayori, Kim, Yoshiharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216608/
https://www.ncbi.nlm.nih.gov/pubmed/22355644
http://dx.doi.org/10.1038/srep00127
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author Kuriyama, Kenichi
Honma, Motoyasu
Shimazaki, Miyuki
Horie, Michiko
Yoshiike, Takuya
Koyama, Sayori
Kim, Yoshiharu
author_facet Kuriyama, Kenichi
Honma, Motoyasu
Shimazaki, Miyuki
Horie, Michiko
Yoshiike, Takuya
Koyama, Sayori
Kim, Yoshiharu
author_sort Kuriyama, Kenichi
collection PubMed
description Working memory (WM) capacity improvement is impacted by sleep, and possibly by N-methyl-D-aspartate (NMDA) agonists such as D-cycloserine (DCS), which also affects procedural skill performance. However, the mechanisms behind these relationships are not well understood. In order to investigate the neural basis underlying relationships between WM skill learning and sleep, DCS, and both sleep and DCS together, we evaluated training-retest performances in the n-back task among healthy subjects who were given either a placebo or DCS before the task training, and then followed task training sessions either with wakefulness or sleep. DCS facilitated WM capacity enhancement only occurring after a period of wakefulness, rather than sleep, indicating that WM capacity enhancement is affected by a cellular heterogeneity in synaptic plasticity between time spent awake and time spent asleep. These findings may contribute to development, anti-aging processes, and rehabilitation of higher cognition.
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spelling pubmed-32166082011-12-22 An N-methyl-d-aspartate receptor agonist facilitates sleep-independent synaptic plasticity associated with working memory capacity enhancement Kuriyama, Kenichi Honma, Motoyasu Shimazaki, Miyuki Horie, Michiko Yoshiike, Takuya Koyama, Sayori Kim, Yoshiharu Sci Rep Article Working memory (WM) capacity improvement is impacted by sleep, and possibly by N-methyl-D-aspartate (NMDA) agonists such as D-cycloserine (DCS), which also affects procedural skill performance. However, the mechanisms behind these relationships are not well understood. In order to investigate the neural basis underlying relationships between WM skill learning and sleep, DCS, and both sleep and DCS together, we evaluated training-retest performances in the n-back task among healthy subjects who were given either a placebo or DCS before the task training, and then followed task training sessions either with wakefulness or sleep. DCS facilitated WM capacity enhancement only occurring after a period of wakefulness, rather than sleep, indicating that WM capacity enhancement is affected by a cellular heterogeneity in synaptic plasticity between time spent awake and time spent asleep. These findings may contribute to development, anti-aging processes, and rehabilitation of higher cognition. Nature Publishing Group 2011-10-24 /pmc/articles/PMC3216608/ /pubmed/22355644 http://dx.doi.org/10.1038/srep00127 Text en Copyright © 2011, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareALike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Article
Kuriyama, Kenichi
Honma, Motoyasu
Shimazaki, Miyuki
Horie, Michiko
Yoshiike, Takuya
Koyama, Sayori
Kim, Yoshiharu
An N-methyl-d-aspartate receptor agonist facilitates sleep-independent synaptic plasticity associated with working memory capacity enhancement
title An N-methyl-d-aspartate receptor agonist facilitates sleep-independent synaptic plasticity associated with working memory capacity enhancement
title_full An N-methyl-d-aspartate receptor agonist facilitates sleep-independent synaptic plasticity associated with working memory capacity enhancement
title_fullStr An N-methyl-d-aspartate receptor agonist facilitates sleep-independent synaptic plasticity associated with working memory capacity enhancement
title_full_unstemmed An N-methyl-d-aspartate receptor agonist facilitates sleep-independent synaptic plasticity associated with working memory capacity enhancement
title_short An N-methyl-d-aspartate receptor agonist facilitates sleep-independent synaptic plasticity associated with working memory capacity enhancement
title_sort n-methyl-d-aspartate receptor agonist facilitates sleep-independent synaptic plasticity associated with working memory capacity enhancement
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216608/
https://www.ncbi.nlm.nih.gov/pubmed/22355644
http://dx.doi.org/10.1038/srep00127
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